Browsing by Author "Spuches, Anne M."
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Calorimetric Investigation of Copper Binding in the N-Terminal Region of the Prion Protein at Low Copper Loading: Evidence for an Entropically Favorable First Binding Event
Gogineni, Devi Praneetha; Spuches, Anne M.; Burns, Colin Sanderson (2015-12) -
Cu²⁺ Binding to A[beta] peptides : Detailed Heat Capacity Studies Provide Structural Insight into Complex Formation
Gade, Sunitha (East Carolina University, 2012)Alzheimer's disease (AD), an irreversible, progressive and devastating neurodegenerative disease, is the most common cause of dementia. It is characterized by the extracellular amyloid plaques and the intracellular ... -
A quantitative and nondestructive method for determining the degradation of waterlogged archaeological wood
Bingham, Jessica (East Carolina University, 2013)Archaeological artifacts are an essential part of preserving history and culture, and can be valuable tools for enhancing education and contributing economic benefits through tourism. Of the artifacts that one may encounter, ... -
Thermodynamic Investigation into the Binding Properties of Cardiac Troponin (Human and Bovine)
Haulsee, Zachary Merle (East Carolina University, 2010)Troponin is an integral protein in the mechanism of muscle contraction. In order to induce cardiac muscle contraction, Ca[superscript]2[superscript]+ must bind to the TnC subunit (calcium binding subunit) of troponin to ... -
Thermodynamic Investigation of Copper Binding to the Amyloid-Beta (A[beta]) Peptide
Sacco, Cristina (East Carolina University, 2010)Alzheimer's disease is a fatal and neurodegenerative disease with as many as 5.3 million Americans living with the disease. One of the characteristic hallmarks of Alzheimer's is the amyloid plaques that build up around the ... -
Thermodynamic studies of Ca²⁺ binding to human cardiac troponin C
Skowronsky, Rachel Ann (East Carolina University, 2012)Human Cardiac Troponin C (HcTnC) is an EF hand protein responsible for initiating contraction of the myocardium (heart muscle). The helix-loop-helix motif, characteristic of members of the EF-hand family, allows HcTnC to ...