Browsing by Author "Ulivi, Paola"
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Healthy CD4+ T lymphocytes are not affected by targeted therapies against the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia
Alameen, Ayman A.M.; Simioni, Carolina; Martelli, Alberto; Zauli, Giorgio; Ultimo, Simona; McCubrey, James A.; Gonelli, Arianna; Marisi, Giorgia; Ulivi, Paola; Capitani, Silvano; Neri, Luca (2016-08-01)An attractive molecular target for novel anti-cancer therapies is the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway which is commonly deregulated in many types of cancer. Nevertheless, ... -
PI3K isoform inhibition associated with anti Bcr-Abl drugs shows in vitro increased anti-leukemic activity in Philadelphia chromosome-positive B-acute lymphoblastic leukemia cell lines
Ultimo, Simona; Simioni, Carolina; Martelli, Alberto M.; Zauli, Giorgio; Evangelisti, Camilla; Celeghini, Claudio; McCubrey, James A.; Marisi, Giorgia; Ulivi, Paola; Capitani, Silvano; Neri, Luca M. (2017-02-20)B-acute lymphoblastic leukemia (B-ALL) is a malignant disorder characterized by the abnormal proliferation of B-cell progenitors. Philadelphia chromosome-positive (Ph+) B-ALL is a subtype that expresses the Bcr-Abl fusion ...