Browsing by Subject "Akt, mTOR, Targeted Therapy, Drug Resistance"

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  • Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapy 

    Sokolosky, Melissa L.; Stadelman, Kristin M.; Chappell, William H.; Abrams, Stephen L.; Martelli, Alberto M.; Stivala, Franca; Libra, Massimo; Nicoletti, Ferdinando; Drobot, Lyudmyla B.; Franklin, Richard A.; Steelman, Linda S.; McCubrey, James A. (2011-07-01)
    Elucidating the response of breast cancer cells to chemotherapeutic and hormonal based drugs is clearly important as these are frequently used therapeutic approaches. A signaling pathway often involved in chemo- and ...