Browsing by Subject "Alzheimer's disease"
Now showing items 1-15 of 15
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AGE-DEPENDENT STUDY OF PATHOLOGICAL PROGRESSION OF ALZHEIMER’S DISEASE IN HIPPOCAMPAL AND CORTICAL TISSUE OF HUMAN AND AN AD MOUSE MODEL
(East Carolina University, 2019-05-02)Degeneration of synaptic plasticity plays a critical role in Alzheimer’s disease (AD) pathogenesis. Recent studies have suggested that neuroinflammation may contribute to this degeneration by disrupting the amyloid metabolism ... -
Alzheimer’s Care: Getting Better
(2015)As I was growing up, I still remember going to my grandparents’ house every day after elementary school and eating orange sherbet, riding bikes around the neighborhood, and going to the library to get books to read. I ... -
Amyloid-beta peptide A beta p3-42 affects early aggregation of full-length A beta 1-42
(East Carolina University, 2009-05)The major amyloid beta (Aβ) peptides found in the brain of familial and late onset Alzheimer’s disease include the full-length Aβ1-42 and N-terminally truncated, pyroglutamylated peptides Aβp3-42 and Aβp11-42. The ... -
Aβ peptides and the exposure of their hydrophobic residues upon copper(ii) complex formation: probing mechanisms of amyloid plaque formation in human and rat peptide complexes
(2015-04)Alzheimer’s Disease (AD) is a progressive, neurodegenerative disease that affects 35 million people worldwide and is the 6th leading cause of death in the United States. AD is characterized by neurofibrillary tangles and ... -
Cu²⁺ Binding to A[beta] peptides : Detailed Heat Capacity Studies Provide Structural Insight into Complex Formation
(East Carolina University, 2012)Alzheimer's disease (AD), an irreversible, progressive and devastating neurodegenerative disease, is the most common cause of dementia. It is characterized by the extracellular amyloid plaques and the intracellular ... -
Developmental lead exposure and the exacerbation of Alzheimer's pathology: an immunological analysis
(East Carolina University, 2014)Early neuroimmune dysfunction may play a driving role in the etiopathology of Alzheimer's disease (AD), stemming from the hypothesis that many late-stage adult diseases have an early-life basis. Here we explore whether ... -
Early Metabolic Differences in Alzheimer’s Disease Mouse Model and Exercise Intervention Treatment
(East Carolina University, 2017-06-22)Alzheimer's disease (AD) is a neurodegenerative disorder that affects the central nervous system (CNS). In this study, we characterized and examined the early metabolic changes of the triple transgenic Alzheimer's disease ... -
THE EFFECTS OF PRENATAL LEAD EXPOSURE ON THE DEVELOPMENT OF BIOMARKERS OF ALZHEIMER’S DISEASE
(2015-04)While often well known for its adverse effects on memory, Alzheimer’s disease (AD) is also noteworthy for being the sixth leading cause of death in the United States. An estimated 5.2 million Americans had the disease as ... -
Healthy Aging Effects on Semantic Processing of Faces and Objects
(East Carolina University, 2019-05-01)Neurodegenerative disorders such as Alzheimer's disease (AD) and mild cognitive impairment (MCI) remain significant health and economic burdens, affecting millions worldwide. Creating affordable and accurate early diagnostic ... -
Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains
(East Carolina University, 2009-02-25)Mutations in the DJ-1 gene have been linked to autosomal recessive familial Parkinson's disease. To understand the function of DJ-1, we determined the DJ-1 expression in both zebrafish and post mortem human brains. We found ... -
Installation of Metal-Binding Functionality at Lysine Residues via Azide-Alkyne "Click Chemistry"
(2015-04-29)A novel non-natural amino acid designed to bind divalent metal ions, dubbed Lys(PYRIT), was prepared in a “click reaction” by treating Fmoc-Lys(N3)-OH with 2-ethynylpyridine and Cu(I). It was incorporated into a 12-residue ... -
Investigating the Relationship between Environmental Lead Exposures and the Onset of Alzheimer's Disease Pathologies
(2014)It is been estimated that nearly 5 million Americans suffer from Alzheimer's Disease (AD), making finding its cause one of medicine's top priorities. It has long been known that genetics plays a major role in the development ... -
Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover
(East Carolina University, 2006-12-29)Although delta-catenin/neural plakophilin-related armadillo protein (NPRAP) was reported to interact with presenilin-1 (PS-1), the effects of PS-1 on delta-catenin have not been established. In this study, we report that ... -
Small Molecule, Non-Peptide p75NTR Ligands Inhibit Aß-Induced Neurodegeneration and Synaptic Impairment
(East Carolina University, 2008-11-03)The p75 neurotrophin receptor (p75NTR) is expressed by neurons particularly vulnerable in Alzheimer’s disease (AD). We tested the hypothesis that non-peptide, small molecule p75NTR ligands found to promote survival signaling ... -
Thermodynamic Investigation of Copper Binding to the Amyloid-Beta (A[beta]) Peptide
(East Carolina University, 2010)Alzheimer's disease is a fatal and neurodegenerative disease with as many as 5.3 million Americans living with the disease. One of the characteristic hallmarks of Alzheimer's is the amyloid plaques that build up around the ...