Browsing by Subject "Biology, Cellular"
Now showing items 1-14 of 14
-
Activation of GPR4 by acidosis inhibits tumor cell migration, invasion and metastasis.
(East Carolina University, 2011)Melanoma and Prostate Cancer are two of the most diagnosed forms of cancer in the United States. The ability to metastasize and colonize in a distant location is one of the most devastating hallmarks of cancer as modes ... -
Activation of the proton sensing G-protein coupled receptor, GPR4, regulates focal adhesion dynamics and delays cell spreading due to increased cytoskeletal tension
(East Carolina University, 2013)The tumor microenvironment is characteristically acidic due to insufficient blood perfusion, chronic inflammation, hypoxia, and altered cell metabolism. The low pH found in the tumor microenvironment may facilitate the ... -
Adenosine monophosphate-activated protein kinase inhibits vascular smooth muscle growth associated with vasculoproliferative disorders
(East Carolina University, 2013)Vascular growth disorders are the major contributing factor to cardiovascular disease, the leading cause of morbidity and mortality worldwide. Aberrant vascular smooth muscle cell (VSMC) growth is a primary etiology ... -
Cardiac and Mitochondrial Adaptations in Response to Aging and Doxorubicin in Rats Bred for Divergent Aerobic Capacities
(East Carolina University, 2012)Doxorubicin (DOX) remains as one of the most widely prescribed and effective anticancer agents. A major limitation of the therapeutic effectiveness of the drug is the occurrence of irreversible, progressive, dose-dependent ... -
CD44 and hyaluronan promote the bmp7 signaling response in chondrocytes
(East Carolina University, 2011)Cell-matrix interactions are important in maintaining cartilage homeostasis. Hyaluronan binding to its principal receptor CD44 is essential for such interactions. Hyaluronan-CD44 interactions are required for the retention ... -
Claudin-7 increases chemosensitivity to cisplatin in human NCI-H522 lung cancer cells
(East Carolina University, 2010)Lung cancer is a leading cause of cancer death for both men and women worldwide. The 5-year survival rate for lung cancer is only 15%, and it accounts for approximately 1.4 million deaths every year. Recently, it has ... -
COMPARATIVE ANALYSIS OF TWO HUMAN CANCER CELL LINES FOLLOWING EXPOSURE TO LOW DOSE RADIATION
(East Carolina University, 2011)Over the past two decades, studies on the cellular response to very low dose radiation have been revolutionizing historically-held paradigms of cellular radioresponse. Indeed, a host of seemingly contradictory events have ... -
COMPARISON OF TWO HUMAN CELL LINES FOLLOWING EXPOSURE TO LOW DOSE RADIATION AND TREATMENT WITH SOYBEAN MISO AND ITS ACTIVE INGREDIENT GENISTEIN
(East Carolina University, 2013)Exposure to radiation is increasingly becoming a worldwide health issue. Because of this, the need for effective radioprotectors is critical. This need is not met by amifostine, the current "gold standard" in radioprotectors, ... -
An examination of the functional role of TMEFF2 in prostate cancer and the translational regulatory mechanisms controlling its expression
(East Carolina University, 2012)Prostate cancer is the most commonly diagnosed cancer in American men and accounts for approximately 11% of cancer-related deaths. Although promising treatment strategies have been developed and are currently being tested ... -
Genetic and hypoxic effects on germline tumor development in caenorhabditis elegans
(East Carolina University, 2013)The process of differentiation of stem cells to committed, progenitor specific cell types is well studied but the reverse process of the dedifferentiation of these committed cells back to the undifferentiated state still ... -
Photofrin-Mediated Electroporation-Assisted Photodynamic Therapy of MCF-7 Human Breast Cancer and B16-F10 Mouse Melanoma Cells
(East Carolina University, 2011)Photodynamic therapy is a relatively new player on the field of cancer treatment that involves the injection of a nontoxic light-sensitive drug followed by light excitation, creating reactive oxygen species that cause ... -
The Role of eIF4G-1 Isoforms and Live Cell Imaging of IRES-mediated Translation Initiation in Breast Cancer Cells
(East Carolina University, 2012)The development of cancer is a consequence of mutations that lead to dysfunctional cell processes such as unrestrained cell proliferation, resistance to apoptosis, and improper regulation of cell processes such as translation. ... -
SYNAPTOPODIN-2 ISOFORM A AND D EXPRESSION IN HT-29 HUMAN COLON ADENOCARCINOMA CELLS
(East Carolina University, 2013)Synaptopodin-2 is a largely unfolded actin-binding protein that also possesses the characteristics of a hub protein. Synaptopodin-2 has other known binding partners such as filamin and [alpha]-actinin (Weins, et al. 2001 ... -
The therapeutic potential of Rho GTPase intervention
(East Carolina University, 2013)Small GTPases of the Rho family are well established regulators of critical cellular functions including cytoskeletal remodeling, motility, vesicle trafficking and cell cycle control. Additionally, aberrant signaling ...