Browsing by Subject "C. elegans"
Now showing items 1-20 of 20
-
Assessing cellular and genomic damage from environmental nickel using a GFP containing strain of Caenorhabditis elegans
(East Carolina University, 2013)Nickel is a naturally found mineral that has become widely used for many electronic devices. As use and subsequent discarding of nickel containing products continues exposure to nickel increases. Nickel can cause external ... -
Characterizing Multigenerational Effects of Nicotine-Dependent Behaviors in Caenorhabditis Elegans
(East Carolina University, 2017-05-03)This project aims to investigate the effects nicotine, a highly addictive chemical associated with tobacco smoking, have on offspring (F1 and F2) using the model organism Caenorhabditis elegans (C. elegans). C. elegans is ... -
Comparison of ZnO nanoparticles and ZnCl₂ induced germ cell apoptosis in Caenorhabditis elegans
(East Carolina University, 2014)There is inadequate research data available on manufactured ZnO nanoparticles. Manufactured nanoparticles are widely used in various products and production of manufactured nanoparticles is becoming increasingly abundant. ... -
Effects of Nicotine on Caenorhabditis elegans survival, reproduction, and gene expressions : Development of an Invertebrate Animal Model for Drugs of Abuse
(East Carolina University, 2011)Although much is known about the addictive effects of nicotine, the molecular mechanisms of nicotine-induced effects remain largely unclear. Specifically, little is known about the effects of nicotine on gene expression, ... -
The Evolution of Organ Shape : Distal Tip Cell Migration and Gonadogenesis in Nematodes
(East Carolina University, 2013)Animals display a variety of shapes in nature. The different shape of homologous organs allows them to adopt different functions and therefore, allows animals to live in different ecological niches. However, little is ... -
Fundamental and Applied Studies on Chromatographic Separation of Cold Drugs and Skincare Creams and Extraction of Salvia miltiorrhiza using Subcritical Water
(East Carolina University, 2014)Subcritical water chromatography (SBWC) and subcritical water extraction (SBWE) are two green techniques that use subcritical water as the sole solvent for separations, thus eliminating the use of toxic and expensive organic ... -
Genetic and hypoxic effects on germline tumor development in caenorhabditis elegans
(East Carolina University, 2013)The process of differentiation of stem cells to committed, progenitor specific cell types is well studied but the reverse process of the dedifferentiation of these committed cells back to the undifferentiated state still ... -
Genetic control of cell fate specification in Caenorhabditis elegans germline.
(East Carolina University, 2015)The precise regulation of germ cell fates (sperm or oocyte) lies at the heart of reproduction and fertility. The nematode Caenorhabditis elegans hermaphrodites produce a discrete number of sperm during larval development ... -
Investigating the Effects of Sodium Benzoate on Fat Deposition and Pharyngeal Pumping and Related Genetic Mechanism in Caenorhabditis elegans
(East Carolina University, 2022-07-18)Sodium benzoate is a widely used food preservative common in many household products due to its antibacterial and antifungal activities. However, many of its side effects other than as a preservative has been under research ... -
Investigating the Effects of Sodium Benzoate on Fat Deposition and Pharyngeal Pumping and Related Genetic Mechanism in Caenorhabditis elegans
(East Carolina University, 2022-07-18)Sodium benzoate is a widely used food preservative common in many household products due to its antibacterial and antifungal activities. However, many of its side effects other than as a preservative has been under research ... -
Nicotine Controlof Germline Cell Fate in Caenorhabditis elegans
(2015-05)Nicotine dependence is the single largest cause of preventable death in the world, claiming 480,000 lives each year in the US alone, including those caused by secondhand smoke. In this study, we investigated the biological ... -
Nicotine exposure caused significant transgenerational heritable behavioral changes in Caenorhabditis elegans
(2013-09)Passive and active exposure to tobacco smoking among youth is directly associated with immediate as well as long-term health deterioration. Despite all public health policies and efforts, the percentage of teenage smokers ... -
Selective Recruitment of Germ Cell mRNAs by eIF4 Factors
(East Carolina University, 1/13/16)During germ line development critical steps in the proliferation and differentiation of stem cells into oocytes and sperm are regulated by mRNA translational control. This regulation changes the subset of proteins being ... -
Sub-lethal toxic effect of Bisphenol A on Caenorhabditis elegans : the role of stress resistance genes in BPA-induced growth inhibition
(East Carolina University, 2014)Endocrine disrupting chemicals (EDCs) have become of concern for a variety of health issues. Bisphenol-A (BPA) is a widely studied EDC and has been characterized by its estrogen-like effects. BPA is a prevalent component ... -
Three Generations, One Future: A Systematic Analysis on Nicotine's Effect across generations in C. elegans.
(East Carolina University, 2013)Tobacco smoking is a worldwide epidemic that is responsible for diseases and death rates that surpass those attributed to a combination of other causes (e.g. cancer, HIV, accidents). A major mediator of tobacco-smoke related ... -
Toxic Effects of Chlorpyrifos Exposure on Development of Caenorhabditits Elegans
(East Carolina University, 2016-12-15)Chlorpyrifos is a commonly utilized organophosphate pesticide, and as recently as 2007, was the most commonly used insecticide within the United States. Its ubiquity is concerning given its potential to cause developmental ... -
TOXICITY OF METAL OXIDE NANOPARTICLES TO CAENORHABDITIS ELEGANS
(East Carolina University, 2012)The increase in manufacturing and use of nanoparticles is expected to elevate levels of exposure to humans and other organisms. Presently, there is little understanding of the potential toxic effects of nanoparticle exposure. ...