Browsing by Subject "DNA methylation"
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Electrochemical Detection of DNA Methylation and Implications for Detection of Cancer Onset Resulting from Hypermethylation
(East Carolina University, 2017-05-05)Epigenetics refers to the process by which genetic material is modified without changing the base coding sequence1. One such epigenetic process is DNA methylation, employed by cells to regulate gene expression, often by ... -
Epigenetic mechanisms of drug resistance: drug-induced DNA hypermethylation and drug resistance.
(East Carolina University, 1993-04-01)In a model system employing Chinese hamster V-79 cells, the DNA synthesis inhibitor 3'-azido-3'- deoxythymidine (BW A509U, AZT) was shown to induce genome-wide DNA hypermethylation, low-frequency silencing of thymidine ...