Browsing by Subject "Developmental biology"
Now showing items 1-17 of 17
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Characterization Of 'Fuzzy Tassel' Male Sterility Defects Implicates Novel MiRNA-Regulated Pathways In Maize Stamen Development
(East Carolina University, 2015)The maize 'fuzzy tassel' ('fzt') mutant is caused by a mutation in 'dicer-like1' and has broad developmental defects. 'dicer-like1' encodes a key enzyme for microRNA (miRNA) biogenesis and many miRNAs are reduced in 'fzt' ... -
CHARACTERIZATION OF MIGRATING NEURAL CREST CELLS FROM HINDBRAIN EXPLANTS IN ZEBRAFISH
(East Carolina University, 2010)Our lab was interested in creating a reproducible mechanism for obtaining neural crest cells in culture from cultured hindbrain explants of zebrafish. We have characterized the population of cells migrating from the ... -
Characterization of MiR319-Regulated TCPs in Maize Development
(East Carolina University, 1/13/16)Maize produces two inflorescences, the tassel and the ear, that are essential for reproduction. Both inflorescences arise from similar inflorescence primordia and are patterned largely by the same developmental regulators. ... -
Characterizing the Expression Pattern of miR167-Regulated ZmArf3 and ZmArf30 in Maize Inflorescences
(East Carolina University, 2014)Plant growth and development depends on the activity of meristems, pools of stem cells that generate leaves and other organs. Maize (corn) produces two inflorescences, the tassel and ear, which are patterned by a series ... -
Characterizing the vegetative phenotype of fzt maize mutant
(East Carolina University, 2012)microRNAs are short, non-coding RNA strands that regulate gene expression post-transcriptionally in all multicellular organisms. miRNAs begin as a hairpin in the nucleus. The primary miRNA (pri-miRNA) and preliminary ... -
Control of maize development by microRNA and auxin regulated pathways
(East Carolina University, 2018-12-10)Plant architecture and inflorescence architecture, in particular, are major determinates of yield. Plant architecture is dependent upon the activity of meristems. Meristems are vital to plant development because they not ... -
Developmental lead exposure and the exacerbation of Alzheimer's pathology: an immunological analysis
(East Carolina University, 2014)Early neuroimmune dysfunction may play a driving role in the etiopathology of Alzheimer's disease (AD), stemming from the hypothesis that many late-stage adult diseases have an early-life basis. Here we explore whether ... -
Effect of Versican G1 Domain Overexpression on Hyaluronan, Hyaluronidase-2, and Synovial Joint Formation in the Embryonic Chick
(East Carolina University, 2013)Versican, an extracellular chondroitin sulfate proteoglycan which binds hyaluronan, has been hypothesized to play a role in synovial joint formation in the chick embryo. Several studies have shown versican to be involved ... -
Evaluating The Essential Functions Of The Replication Factor Mcm10 In Drosophila Melanogaster
(East Carolina University, 2015)Often referred to as miraculous, life as we know depends not upon miracles but on a series of highly orchestrated and regulated biochemical processes collectively known as the cell cycle. It is through these series of ... -
Genetic control of cell fate specification in Caenorhabditis elegans germline.
(East Carolina University, 2015)The precise regulation of germ cell fates (sperm or oocyte) lies at the heart of reproduction and fertility. The nematode Caenorhabditis elegans hermaphrodites produce a discrete number of sperm during larval development ... -
The immune and neurological impacts of developmental Bisphenol A exposure in a C57bl/6 mouse model
(East Carolina University, 2014)Environmental exposure to exogenous agents during critical time points of development may be associated with the onset of deleterious effects, including immune and neurological disorders. Numerous studies have shown that ... -
Multiple Translation Factor eIF4G (IFG-1) Isoforms are Required for the Apoptosome-Dependent Activation of Germ Cell Apoptosis
(East Carolina University, 2010)Apoptosis is a naturally occurring process during animal development required for the programmed killing and removal of injured cells. Cellular insult induces a switch in translation that allows for the rapid synthesis ... -
PROLACTIN FUNCTION IN ZEBRAFISH DEVELOPMENT
(East Carolina University, 2010)Extensive studies have implicated a myriad of functional roles for prolactin (PRL) and prolactin receptor (PRLR) across a variety of adult vertebrate species. However, much less is known about the physiological role(s) of ... -
Selective Recruitment of Germ Cell mRNAs by eIF4 Factors
(East Carolina University, 1/13/16)During germ line development critical steps in the proliferation and differentiation of stem cells into oocytes and sperm are regulated by mRNA translational control. This regulation changes the subset of proteins being ... -
SPATIAL EXPRESSION OF MATRIX AND MATRIX RECEPTOR PROTEINS IN THE DEVELOPING SYNOVIAL JOINT
(East Carolina University, 2013)Little is understood about the complex spatial and temporal molecular interactions necessary to form a fully functional synovial joint. Understanding molecular pathways and signaling within the developing joint continues ... -
Species And Stage Specific Developmental Toxicity Of Endosulfan Exposure In Hyla Cinerea And Ranitomeya Imitator
(East Carolina University, 2015)During ontogeny, organisms pass through critical periods of heightened vulnerability to disruptive exogenous agents. In organisms with complex life cycles, these developmental windows result in variable susceptibility ... -
VALIDATION OF CANDIDATE GENES IN RESPONSE TO VERSICAN MANIPULATION IN DEVELOPING SYNOVIAL JOINTS
(East Carolina University, 2012)Little is understood about the complex process of synovial joint formation in early limb development. It has been shown that versican is highly expressed in the extracellular matrix of these joints (Snow et al., 2005; ...