Browsing by Subject "GPR4"
Now showing items 1-4 of 4
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Acidic tumor microenvironment and pH-sensing G protein-coupled receptors
(2013-10)The tumor microenvironment is acidic due to glycolytic cancer cell metabolism, hypoxia, and deficient blood perfusion. It is proposed that acidosis in the tumor microenvironment is an important stress factor and selection ... -
Activation of GPR4 by acidosis inhibits tumor cell migration, invasion and metastasis.
(East Carolina University, 2011)Melanoma and Prostate Cancer are two of the most diagnosed forms of cancer in the United States. The ability to metastasize and colonize in a distant location is one of the most devastating hallmarks of cancer as modes ... -
Can GPR4 be a potential therapeutic target for COVID-19?
(2021-01-21)Coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first emerged in late 2019 and has since rapidly become a global pandemic. SARS-CoV-2 infection causes damages to ... -
The Functional Roles of pH-sensing G protein-coupled receptors in Intestinal Inflammation
(East Carolina University, 2018-12-06)The inflammatory microenvironment in inflammatory bowel disease (IBD) is complex, replete with microbial byproducts, complement, leukocytes, and resulting inflammatory cytokines. Parallel to these microenvironmental factors ...