Browsing by Subject "Inflammation"
Now showing items 1-15 of 15
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Analysis of Complex DNA Damage Associated with Tumor Growth
(East Carolina University, 2012)The innate response of a fully functioning immune system's ability to recognize and react to the growth of a tumor by releasing reactive oxygen species (ROS) may lead to chronic inflammation in many cases. This chronic ... -
EFFECTS OF A 16 WEEK PHYSICAL ACTIVITY INTERVENTION ON SERUM C-REACTIVE PROTEIN CONCENTRATIONS IN 8-11 YEAR OLD AFRICAN AMERICAN AND CAUCASIAN CHILDREN.
(East Carolina University, 2013)C-reactive protein (CRP) is a non-specific marker of systemic inflammation that has been associated with heart disease, obesity, and metabolic disorders in adults and children. Previous physical activity interventions have ... -
Elevated Endogenous Erythropoietin Concentrations Are Associated with Increased Risk of Brain Damage in Extremely Preterm Neonates
(2015-03)Background We sought to determine, in very preterm infants, whether elevated perinatal erythropoietin (EPO) concentrations are associated with increased risks of indicators of brain damage, and whether this risk differs ... -
G Protein-Coupled Receptor Signaling in Growth and Inflammation of Vascular Smooth Muscle
(East Carolina University, 2021-06-22)Cardiovascular disease (CVD) remains the primary cause of morbidity and mortality in the United States and worldwide. The exaggerated release of serine proteases and reduced blood flow and ensuing development of extracellular ... -
Impaired T cell-mediated hepatitis in peroxisome proliferator activated receptor alpha (PPARα)-deficient mice
(2018-02-15)Background Peroxisome proliferator activated receptor alpha (PPARα), a regulator of enzymes involved in β oxidation, has been reported to influence lymphocyte activation. The purpose of this study was to determine whether ... -
Induced ablation of skeletal muscle-specific estrogen receptor-alpha in adult female mice increased the susceptibility to develop skeletal muscle inflammation and glucose intolerance under chronic lipid overload
(East Carolina University, 2018-04-27)Skeletal muscle-specific ER[alpha] appears to play important roles in regulating skeletal muscle glucose and lipid homeostasis. The overall aim of this dissertation was to determine whether skeletal muscle-specific ER[alpha] ... -
The induction of antigen-specific immunological tolerance and attenuation of inflammation via cytokine antigen fusion protein therapy in a mouse model of pulmonary inflammation
(East Carolina University, 2014)Allergic asthma is a significant medical issue, affecting more than 300 million individuals and causing approximately 250,000 deaths each year. Current asthma therapies temporarily minimize discomfort and manage symptoms, ... -
Intratracheal instillation of silver nanoparticles exacerbates cardiac ischemia/reperfusion injury in male sprague-dawley rats
(East Carolina University, 2014)The uses of engineered nanomaterials have expanded in biomedical technology and consumer manufacturing. Exposure to particulate matter has been demonstrated to negatively influence cardiovascular health and expand myocardial ... -
Molecular Mechanisms Underlying Cannabidiol-Improved Vocal Recovery Following Damage to a Songbird Vocal Pre-Motor Cortical-Like Region
(East Carolina University, 2023-04-27)The non-euphorigenic phytocannabinoid CBD has been found to be effective in treating childhood-onset epilepsies, conditions that are often associated with developmental delays, including vocal communication. Zebra finch ... -
Neurogenic switching: a hypothesis for a mechanism for shifting the site of inflammation in allergy and chemical sensitivity.
(East Carolina University, 1995-01)Neurogenic switching is proposed as a hypothesis for a mechanism by which a stimulus at one site can lead to inflammation at a distant site. Neurogenic inflammation occurs when substance P and other neuropeptides released ... -
Oral health, diabetes, and inflammation: Effects of oral hygiene behavior
(Elsevier, 2021-11-29)The aim of this research was to assess the association between inflammation and oral health and diabetes, as well as the mediating role of oral hygiene practice in this association. Data were from the 2009–2010 National ... -
Relationships between Adipose Tissue and Cytokine Responses to a Randomized Controlled Exercise Training Intervention
(East Carolina University, 2008-04)Adipose-derived cytokines play a prominent role in mediating the metabolic consequences of obesity and excess body fat. Given this, we hypothesized that alterations in adipose tissue stores incurred with exercise training ... -
Resolution of Chronic Granulomatous Inflammation and Fibrosis in a Murine Model of Sarcoidosis
(East Carolina University, 2021-07-14)Sarcoidosis is a chronic granulomatous disease of unknown cause. Granulomas resolve within 12-26 months in 50% of cases without therapy while 30% of patients have chronic disease that progresses to pulmonary fibrosis. The ... -
The Functional Roles of pH-sensing G protein-coupled receptors in Intestinal Inflammation
(East Carolina University, 2018-12-06)The inflammatory microenvironment in inflammatory bowel disease (IBD) is complex, replete with microbial byproducts, complement, leukocytes, and resulting inflammatory cytokines. Parallel to these microenvironmental factors ... -
THE ROLE OF THE ALVEOLAR MACROPHAGE IN CARBON NANOTUBE ELICITED MURINE MODEL OF PULMONARY GRANULOMATOUS INFLAMMATION
(East Carolina University, 2018-11-29)Pulmonary sarcoidosis is a debilitating inflammatory condition characterized by the presence of granulomatous lesions throughout the lung. Granulomas are a physiological response to inhaled antigens or particulate matter ...