Now showing items 1-2 of 2

    • The effect of fasting on the activation in vivo of the insulin receptor kinase. 

      Contreras, Ivan; Dohm, G. Lynis; Abdallah, Silvia; Wells, James A.; Mooney, Nitin; Rovira, Adela; Caro, Jose F. (East Carolina University, 1990-02-01)
      Fasting causes insulin resistance in liver and fat, and increases insulin sensitivity in muscle. We studied the response in vitro and in vivo to insulin of the insulin receptor tyrosine kinase in muscle and liver from 72 ...
    • Modulation of IKKβ with AMPK Improves Insulin Sensitivity in Skeletal Muscle 

      Bikman, Benjamin Thomas (East Carolina University, 2008-11)
      Activation of the insulin receptor substrate (IRS)-1 is necessary for proper transduction of the insulin signal. IRS-1 serine312(human)/307(rodent) phosphorylation, however, results in disruption of this signal and subsequent ...