Browsing by Subject "Kremen1"
Now showing items 1-3 of 3
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MicroRNA-431 regulates axon regeneration in mature sensory neurons by targeting the Wnt antagonist
(2013-10)MicroRNAs (miRNAs) are small, non-coding RNAs that function as key post-transcriptional regulators in neural development, brain function, and neurological diseases. Growing evidence indicates that miRNAs are also important ... -
Prevention of synaptic loss in cortico-hippocampal culture by silencing Kremen1 with siRNA
(East Carolina University, 2017-05-19)Research has shown that Alzheimer’s disease could be a result of an accumulation of amyloid β (Aβ) plaques and tau protein. The accumulation of Aβ activates p53, which leads to an increase of Dickkopf-1 (Dkk1). When Dkk1 ... -
Targeting Kremen1 Downregulation with RVG-9R/siRNA Complexes in the Triple-Transgenic Mouse Model of Alzheimer’s Disease
(East Carolina University, 2017-07-19)Alzheimer's disease (AD) is a progressive disease characterized by cognitive decline and memory loss. Memory loss observed in AD results from the loss of neurons and synapses which may be caused by the disruption of the ...