Browsing by Subject "MMP12"
Now showing items 1-5 of 5
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Matrix Metalloproteinase 12 is Critical for Granuloma Formation in the Murine Model of Granulomatous disease
(East Carolina University, 2019-08-16)Matrix Metalloproteinase 12 (MMP12) is a protein produced primarily by alveolar macrophages that degrades elastin in the extracellular matrix (ECM) and enables infiltration of immune cells that participate in the inflammatory ... -
Resolution of Chronic Granulomatous Inflammation and Fibrosis in a Murine Model of Sarcoidosis
(East Carolina University, 2021-07-14)Sarcoidosis is a chronic granulomatous disease of unknown cause. Granulomas resolve within 12-26 months in 50% of cases without therapy while 30% of patients have chronic disease that progresses to pulmonary fibrosis. The ... -
Role of Macrophage Polarization and Apolipoprotein E in Granuloma Resolution
(East Carolina University, 2021-07-06)Sarcoidosis is a chronic disease characterized by the development and accumulation of granulomas. Through multiwall carbon nanotube (MWCNT) instillation of C57 Bl/6 (wild-type) mice, we have established a murine model that ... -
The M2a macrophage phenotype accompanies pulmonary granuloma resolution in Mmp12 knock-out mice instilled with multiwall carbon nanotubes
(MDPI, 2021-10-13)Sarcoidosis is a chronic disease with unknown etiology and pathophysiology, characterized by granuloma formation. Matrix Metalloproteinase-12 (MMP12) is an elastase implicated in active granulomatous sarcoidosis. Previously, ...