Now showing items 1-2 of 2

    • NMR characterizations of an amyloidogenic conformational ensemble of the PI3K SH3 domain 

      Ahn, Hee-Chul; Le, Yen T. H.; Nagchowdhuri, Partha S.; Derose, Eugene F.; Putnam-Evans, Cindy; London, Robert E.; Markley, John L.; Lim, Kwang Hun (East Carolina University, 2006-11)
      Amyloid formation is associated with structural changes of native polypeptides to monomeric intermediate states and their self-assembly into insoluble aggregates. Characterizations of the amyloidogenic intermediate state ...
    • The RXR-alpha C-terminus T462 is a NMR sensor for coactivator peptide binding 

      Lu, Jianyun; Chen, Minghe; DeKoster, Gregory T.; Cistola, David P.; Li, Ellen (East Carolina University, 2008-02-22)
      The C-terminal activation function-2 (AF-2) helix plays a crucial role in retinoid X receptor alpha (RXRα)-mediated gene expression. Here, we report a nuclear magnetic resonance (NMR) study of the RXRα ligand-binding domain ...