Browsing by Subject "Notch"
Now showing items 1-3 of 3
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GSK-3 as potential target for therapeutic intervention in cancer
(2014-05)The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified and studied in the regulation of glycogen synthesis. GSK-3 functions in a wide range of cellular processes. Aberrant activity of GSK-3 ... -
Identification of E2F1 as a positive transcriptional regulator for delta-catenin
(East Carolina University, 2008-05-02)Delta-Catenin is upregulated in human carcinomas. However, little is known about the potential transcriptional factors that regulate delta-catenin expression in cancer. Using a human delta-catenin reporter system, we have ... -
: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification
(2014-09)The nematode Caenorhabditis elegans (C. elegans) offers a unique opportunity for biological and basic medical researches due to its genetic tractability and well-defined developmental lineage. It also provides an exceptional ...