Browsing by Subject "PI3K/Akt/mTOR signaling"

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A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia

Chiarini, Francesca; Lonetti, Annalisa; Teti, Gabriella; Orsini, Ester; Bressanin, Daniela; Cappellini, Alessandra; Ricci, Francesca; Tazzari, Pier Luigi; Ognibene, Andrea; Falconi, Mirella; Pagliaro, Pasqualepaolo; Iacobucci, Ilaria; Martinelli, Giovanni; Amadori, Sergio; McCubrey, James A.; Martelli, Alberto M. (2012-12)

Signaling through the phosphatidylinositol 3-kinase (PI3K) pathway and its downstream effectors, Akt and mechanistic target of rapamycin (mTOR), is aberrantly activated in acute myeloid leukemia (AML) patients, where it ...
Healthy CD4+ T Lymphocytes are Not Affected by Targeted Therapies Against the PI3K/Akt/mTOR Pathway in T-cell Acute Lymphoblastic Leukemia

McCubrey, James A. (2016-08-23)
Synergistic Effects of Selective Inhibitors Targeting the PI3K/AKT/mTOR Pathway or NUP214-ABL1 Fusion Protein in Human Acute Lymphoblastic Leukemia

McCubrey, James A. (2016-11-03)