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  • Adaptive evolution of genes underlying schizophrenia 

    Crespi, Bernard; Summers, Kyle; Dorus, Steve (East Carolina University, 2007-11-22)
    Schizophrenia poses an evolutionary-genetic paradox because it exhibits strongly negative fitness effects and high heritability, yet it persists at a prevalence of approximately 1% across all human cultures. Recent theory ...
  • Mixture modeling with applications in schizophrenia research 

    Wu, Qiang; Sampson, Allan R. (East Carolina University, 2009-05-15)
    Finite mixture modeling, together with the EM algorithm, have been widely used in clustering analysis. Under such methods, the unknown group membership is usually treated as missing data. When the "complete data" ...