Now showing items 1-14 of 14

  • Acidic tumor microenvironment and pH-sensing G protein-coupled receptors 

    Justus, Calvin R.; Dong, Lixue; Yang, Li V. (2013-10)
    The tumor microenvironment is acidic due to glycolytic cancer cell metabolism, hypoxia, and deficient blood perfusion. It is proposed that acidosis in the tumor microenvironment is an important stress factor and selection ...
  • Animal Viruses, Bacteria, and Cancer: A Brief Commentary 

    Efird, Jimmy T.; Davies, Stephen W.; O'Neal, Wesley T.; Anderson, Ethan J. (2014-02)
    Animal viruses and bacteria are ubiquitous in the environment. However, little is known about their mode of transmission and etiologic role in human cancers, especially among high-risk groups (e.g., farmers, veterinarians, ...
  • Electrochemical Detection of DNA Methylation and Implications for Detection of Cancer Onset Resulting from Hypermethylation 

    Gonzalez, Samantha Dawn (East Carolina University, 2017-05-05)
    Epigenetics refers to the process by which genetic material is modified without changing the base coding sequence1. One such epigenetic process is DNA methylation, employed by cells to regulate gene expression, often by ...
  • Exploring Alternative Strategies for the Synthesis of 15d-PGJ2-EA: Diversification of Synthetic Routes to a Potent Anti-Cancer Agent 

    Dorszynski, Amy Lynn (East Carolina University, 2016-04-29)
    The compound, 15-deoxy-12, 14-prostaglandin-J2-ethanolamine (15d-PGJ2-EA), is in an active line of research for treating non-melanoma skin cancer and has shown promising potential as a chemotherapeutic drug. 15d-PGJ2-EA ...
  • Hox-gene expression as a biomarker for igf-1r therapeutics 

    Bertrand, Fred Edmond; Whelan, Jarrett Thomas (2008-09-25)
    This invention provides methods for treating or preventing the onset of a tumor in a subject, wherein the tumor is determined to overexpress a Hox gene, including administering to the subject a therapeutically or ...
  • MCM10 Genetic Screen Using Drosophila melanogaster 

    Dinter, Heinz P (East Carolina University, 2016-04-28)
    Genes and the proteins they encode are responsible for virtually every aspect of life. The vast array of biological processes make it difficult to identify genes to study that are relevant to human diseases. MCM10 (short ...
  • Method of detecting cancer using delta-catenin 

    Lu, Qun; Chen, Yan-hua (2008-11-04)
    The present invention provides a method for detecting or screening for the presence of cancer in a subject. The method comprises obtaining, providing or collecting a tissue or fluid sample (such as a urine sample) from ...
  • Recent discoveries in the cycling, growing and aging of the p53 field 

    McCubrey, James A.; Demidenko, Zoya N. (2012-12)
    The P53 gene and it product p53 protein is the most studied tumor suppressor, which was considered as oncogene for two decades until 1990. More than 60 thousand papers on the topic of p53 has been abstracted in Pubmed. ...
  • Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes 

    Berman, Albert E.; Leontieva, Olga V.; Natarajan, Venkatesh; McCubrey, James A.; Demidenko, Zoya N.; Nikiforov, Mikhail A. (2012-12)
    It is widely believed that aging results from the accumulation of molecular damage, including damage of DNA and mitochondria and accumulation of molecular garbage both inside and outside of the cell. Recently, this paradigm ...
  • Recent progress in targeting cancer 

    Demidenko, Zoya N.; McCubrey, James A. (2011-12)
    In recent years, numerous new targets have been identified and new experimental therapeutics have been developed. Importantly, existing non-cancer drugs found novel use in cancer therapy. And even more importantly, new ...
  • Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer 

    Candido, Saverio; Maestro, Roberta; Polesel, Jerry; Catania, Alessia; Maira, Francesca; Signorelli, Santo S.; McCubrey, James A.; Libra, Massimo (2014-03)
    Cancer remains one of the major cause of death in the Western world. Although, it has been demonstrated that new therapies can improve the outcome of cancer patients, still many patients relapse after treatment. Therefore, ...
  • Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging 

    Steelman, Linda S.; Chappell, William H.; Abrams, Stephen L.; Kempf, C. Ruth; Long, Jacquelyn M.; Laidler, Piotr; Mijatovic, Sanja; Maksimovic-Ivanic, Danijela; Stivala, Franca; Mazzarino, Maria C.; Donia, Marco; Fagone, Paolo; Malaponte, Graziella; Nicoletti, Ferdinando; Libra, Massimo; Milella, Michele; Tafuri, Agostino; Bonati, Antonio; Bäsecke, Jörg; Cocco, Lucio; Evangelisti, Camilla; Martelli, Alberto M.; Montalto, Giuseppe; Cervello, Melchiorre; McCubrey, James A. (2011-03)
    Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these pathways or upstream activators. Unrestricted cellular proliferation ...
  • The Tumor Suppressive Effects of T Cell Death-Associated Gene 8 in Blood Cancers 

    Justus, Calvin Richard (East Carolina University, 2017-03-16)
    In the early twentieth century Otto Warburg recognized a metabolic phenomenon that transpired in cancer cells, currently known as the Warburg Effect. Warburg discovered cancer cells favor glycolysis rather than oxidative ...
  • Tight junction claudin-7 protein modulates multiple processes of cancer progression in human lung cancer cells 

    Kim, Do Hyung (East Carolina University, 2016-05-03)
    Carcinogenesis usually consists of cancer initiation, promotion, and progression. Several tight junction claudin proteins have been identified as tumor suppressors or activators during cancer development. As apical proteins, ...