Browsing by Subject "cell death"
Now showing items 1-5 of 5
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EXPLORING DIFFERENCES IN INDIVIDUAL SUSCEPTIBILITY TO LIPOTOXICITY AND THE UNDERLYING MECHANISMS IN THE MITOCHONDRIA OF PRIMARY PREADIPOCYTES
(East Carolina University, 2018-07-17)Prolonged exposure to fatty acids (FAs), at levels normally seen during fasting, can be cytotoxic in vulnerable cells including preadipocytes. Prior work from our laboratory has shown that FAs cause mitochondrial inner ... -
MOLECULAR MECHANISM OF THE CYTOTOXIC AND IMMUNOSTIMULATORY ACTIVITY OF 15 DEOXY PROSTAMIDE J2: INVESTIGATION OF CHOP10 AND NFĸB SIGNALING IN COLON CANCER
(East Carolina University, 2019-08-13)The endoplasmic reticulum (ER) stress pathway is a prominent regulator of cancer cell death and as a result, ER stress inducers are being exploited pharmacologically. Cytotoxic ER stress is typically regulated by the ... -
SYNTHESIS AND MOLECULAR EVALUATION OF 15-DEOXY-Δ12,14-PROSTAMIDE J2 AS A NOVEL ANTI-SKIN CANCER AGENT
(East Carolina University, 2017-08-16)Skin cancers including non-melanoma skin cancer (NMSC) and melanoma are the most common form of cancer in the United States and thus represent a substantial burden to the health care system. Current chemotherapeutic ...