Now showing items 1-4 of 4

  • Analysis of the mutation in cutaneous melanoma patients with occupational sun exposure 

    Candido, Saverio; Rapisarda, Venerando; Marconi, Andrea; Malaponte, Graziella; Bevelacqua, Valentina; Gangemi, Pietro; Scalisi, Aurora; McCubrey, James A.; Maestro, Roberta; Spandidos, Demetrios A.; Fenga, Concettina; Libra, Massimo (2014-03)
    Sun-exposure is one of the risk factors associated with the development of a cutaneous neoplasm. In melanoma, the Ras-Raf-MEK-ERK (MAPK) signaling pathway is constitutively activated through multiple mechanisms, including ...
  • Emerging targeted therapies for melanoma treatment (Review) 

    Russo, Angela; Ficili, Bartolomea; Candido, Saverio; Pezzino, Franca Maria; Guarneri, Claudio; Biondi, Antonio; Travali, Salvatore; McCubrey, James A.; Spandidos Demetrios A.; Libra, Massimo (2014-08)
    Cutaneous melanoma is an aggressive cancer with a poor prognosis for patients with advanced disease. The identification of several key molecular pathways implicated in the pathogenesis of melanoma has led to the development ...
  • Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma 

    Bevelacqua, Valentina; Bevelacqua, Ylenia; Candido, Saverio; Skarmoutsou, Evangelia; Amoroso, Alfredo; Guarneri, Claudio; Strazzanti, Angela; Gangemi, Pietro; Mazzarino, Maria C.; D'Amico, Fabio; McCubrey, James A.; Libra, Massimo; Malaponte, Graziella (2012-08)
    NECL-5 is involved in regulating cell–cell junctions, in cooperation with cadherins, integrins and platelet-derived growth factor receptor, that are essential for intercellular communication. Its role in malignant ...
  • SYNTHESIS AND MOLECULAR EVALUATION OF 15-DEOXY-Δ12,14-PROSTAMIDE J2 AS A NOVEL ANTI-SKIN CANCER AGENT 

    Ladin, Daniel A (East Carolina University, 2017-08-16)
    Skin cancers including non-melanoma skin cancer (NMSC) and melanoma are the most common form of cancer in the United States and thus represent a substantial burden to the health care system. Current chemotherapeutic ...