Browsing by Subject "metabolism"
Now showing items 1-14 of 14
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Comparison of Mitochondrial Phenotypes Across Cancers with Different Tissues of Origin
(East Carolina University, 2021-12-06)Cancer metabolism is typically characterized by aerobic glycolysis, an increase in glucose uptake and lactate production despite adequate sufficient oxygen availability to support mitochondrial oxidative phosphorylation ... -
Defining the role of acyl-CoA synthetase 6 on α-synucleinopathy
(East Carolina University, 2022-07-19)Background: Neurodegenerative diseases known as α-synucleinopathies, most notably dementias and Parkinson’s Disease (PD), are characterized by neuronal aggregation and accumulation of α-synuclein (α-syn) in a manner that ... -
Defining the role of acyl-CoA synthetase 6 on α-synucleinopathy
(East Carolina University, 2022-07-19)Background: Neurodegenerative diseases known as α-synucleinopathies, most notably dementias and Parkinson’s Disease (PD), are characterized by neuronal aggregation and accumulation of α-synuclein (α-syn) in a manner that ... -
Docosahexaenoic acid-derived metabolites target the B-cell driven immune response in obese mice
(East Carolina University, 2019-06-07)Obesity is associated with an impaired humoral immune response. As B cells mediate the humoral immune response, they are major cellular targets in diet induced obesity models. Several studies have established that B cell ... -
Effects of a high fat diet and/or overload on striated muscle structure, function, or metabolism
(East Carolina University, 2020-12-03)Consumption of a high fat diet combined with physical inactivity is associated with many adverse health effects including obesity, insulin resistance/type 2 diabetes, and cardiovascular disease/myocardial infarction. The ... -
Induced ablation of skeletal muscle-specific estrogen receptor-alpha in adult female mice increased the susceptibility to develop skeletal muscle inflammation and glucose intolerance under chronic lipid overload
(East Carolina University, 2018-04-27)Skeletal muscle-specific ER[alpha] appears to play important roles in regulating skeletal muscle glucose and lipid homeostasis. The overall aim of this dissertation was to determine whether skeletal muscle-specific ER[alpha] ... -
Kinetic and Thermodynamic Contributions to an Intermolecular Mechanism of Subunit Communication: Coordination of Pyruvate Carboxylase Activity Among Spatially Distinct Active Sites
(East Carolina University, 2016-07-13)Catalysis occurring in a multifunctional enzyme at spatially distinct active sites is controlled by an array of factors, including the structure of the enzyme, ligand binding, and productive interaction of substrates to ... -
Tight junction claudin-7 protein modulates multiple processes of cancer progression in human lung cancer cells
(East Carolina University, 2016-05-03)Carcinogenesis usually consists of cancer initiation, promotion, and progression. Several tight junction claudin proteins have been identified as tumor suppressors or activators during cancer development. As apical proteins, ...