Browsing by Subject "mitochondria"
Now showing items 1-13 of 13
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The “Goldilocks Zone� from a redox perspective—Adaptive vs. deleterious responses to oxidative stress in striated muscle
(2014-09)Consequences of oxidative stress may be beneficial or detrimental in physiological systems. An organ system's position on the “hormetic curve” is governed by the source and temporality of reactive oxygen species (ROS) ... -
Muscle Mitochondria in Vascular Disease: A Novel Genetic Target for Limb Salvage
(East Carolina University, 2022-04-19)Peripheral arterial occlusive disease (PAD) is a manifestation of systemic atherosclerosis defined by an occlusion in the peripheral arteries, most commonly those supplying blood to the lower extremities. Chronic limb ... -
Placental Mitochondria Response to Different Modes of Exercise During Pregnancy
(East Carolina University, 2022-08-21)Previous research shows exercise provides health benefits, and this is true in the context of pregnancy. However, little research has been done to examine placenta adaptations to exercise that mediate maternal and fetal ... -
Placental Mitochondria Response to Different Modes of Exercise During Pregnancy
(East Carolina University, 2022-08-21)Previous research shows exercise provides health benefits, and this is true in the context of pregnancy. However, little research has been done to examine placenta adaptations to exercise that mediate maternal and fetal ... -
Tissue-specific characterization of mitochondrial branchedchain keto acid oxidation using a multiplexed assay platform
(East Carolina University, 2021-04-23)Alterations to branched-chain keto acid (BCKA) oxidation have been implicated in a wide variety of human diseases, ranging from diabetes to cancer. Although global shifts in BCKA metabolism-evident by gene transcription, ... -
Why Does Exercise “Trigger� Adaptive Protective Responses in the Heart?
(2015-05)Numerous epidemiological studies suggest that individuals who exercise have decreased cardiac morbidity and mortality. Pre-clinical studies in animal models also find clear cardioprotective phenotypes in animals that ...