Browsing Physiology by Author "Neufer, P. Darrell"
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Cardioprotective mechanisms targeting thiol redox homeostasis and mitochondrial bioenergetics
Alleman, Rick J. (East Carolina University, 2016-05-03)Coronary heart disease is a leading cause of death in the United States, totaled mostly by deaths associated with myocardial infarction and fatal ventricular arrhythmias. The inability to predict the occurrence of these ... -
Deciphering the impact of fructose metabolism on liver mitochondrial bioenergetics
Buddo, Katherine A (East Carolina University, 2021-12-07)Since its discovery in 1980, the interest in nonalcoholic fatty liver disease, the liver manifestation of metabolic syndrome, has expanded due to the growing impact on the world's health. Commonly characterized by ... -
Enhanced Mitochondrial Superoxide Scavenging Does Not Improve Muscle Insulin Action in the High Fat-Fed Mouse
Lark, Daniel Stephen; Kang, Li; Lustig, Mary E.; Bonner, Jeffrey S.; James, Freyja D.; Neufer, P. Darrell; Wasserman, David H. (2015-05)Improving mitochondrial oxidant scavenging may be a viable strategy for the treatment of insulin resistance and diabetes. Mice overexpressing the mitochondrial matrix isoform of superoxide dismutase (sod2tg mice) and/or ... -
Estrogen Receptor-α in Female Skeletal Muscle is Not Required for Regulation of Muscle Insulin Sensitivity and Mitochondrial Regulation
McClung, Joseph M.; Iñigo, Melissa R.; Amorese, Adam J.; Tarpey, Michael D.; Balestrieri, Nicholas P.; Jones, Keith G.; Patteson, Daniel J.; Torres, Maria.J.; Lin, Chien-Te; Smith, Cody D.; Heden, Timothy D.; McMillin, Shawna L.; Weyrauch, Luke A.; Stanley, Erin C.; Schmidt, Cameron A.; Funai, Katsuhiko; Gowdy, Kymberly M.; Witczak, Carol A.; Neufer, P. Darrell; Spangenburg, Espen E. (2020-04-01) -
Exercise-Induced Protection Against Reperfusion Arrhythmia Involves Stabilization of Mitochondrial Energetics
Spangenburg, Espen; Alleman, Rick J.; Tsang, Alvin M.; Ryan, Terence E.; Patteson, Daniel J.; McClung, Joseph M.; Shaikh, Saame Raza; Neufer, P. Darrell; Brown, David A. (2016-05-15) -
Extensive Skeletal Muscle Cell Mitochondriopathy Distinguishes Critical Limb Ischemia Patients from Claudicants
McClung, Joseph M.; Ryan, Terence E.; Yamaguchi, Dean J.; Schmidt, Cameron A.; Zeczycki, Tonya N.; Brophy, Patricia; Green, Thomas D.; Tarpey, Michael D.; Karnekar, Reema; Goldberg, Emma J.; Neufer, P. Darrell; Spangenburg, Espen E. (2018-11-02) -
Genetically Increasing Flux Through b-Oxidation in Skeletal Muscle Increases Mitochondrial Reductive Stress and Glucose Intolerance
Smith, Cody D.; Lin, Chien-Te; McMillin, Shawna L.; Weyrauch, Luke A.; Schmidt, Cameron A.; Smith, Cheryl A.; Witczak, Carol; Neufer, P. Darrell; Kurland, Irwin J. (2021) -
Human Studies of Mitochondrial Biology Demonstrate an Overall Lack of Binary Sex Differences: A Multivariate Meta-Analysis
Fisher-Wellman, Kelsey H.; Neufer, P. Darrell; Junker, Alex (2022) -
Intrinsic OXPHOS Limitations Underlie Cellular Bioenergetics in Leukemia
Nelson, Margaret AM; McLaughlin, Kelsey L.; Hagen, James T.; Coalson, Hannah S.; Schmidt, Cameron; Kassai, Miki; Kew, Kimberly A.; McClung, Joseph M.; Neufer, P. Darrell (2021) -
Linking energy state to redox environment through mitochondrial redox circuits
Smith, Cody D (East Carolina University, 2016-11-16)Mitochondria are the primary producers of intracellular H2O2, an oxidant signaling molecule that has gained attention for its role in normal physiological processes and disease etiologies such as skeletal muscle insulin ... -
Methods for Assessing Mitochondrial Function in Diabetes
Perry, Christopher G.R.; Kane, Daniel A.; Lanza, Ian R.; Neufer, P. Darrell (2013-04)A growing body of research is investigating the potential contribution of mitochondrial function to the etiology of type 2 diabetes. Numerous in vitro, in situ, and in vivo methodologies are available to examine various ... -
Mitochondrial Therapy Improves Limb Perfusion and Myopathy Following Hindlimb Ischemia
McClung, Joseph; Ryan, Terence E.; Schmidt, Cameron A.; Alleman, Rick J.; Tsang, Alvin M.; Green, Thomas D.; Neufer, P. Darrell; Brown, David A. (2016-08-01) -
PFKFB3-Mediated Glycolysis Rescues Myopathic Outcomes in the Ischemic Limb
McClung, Joseph M.; Ryan, Terence E.; Spangenburg, Espen E.; Schmidt, Cameron A.; Tarpey, Michael D.; Amorese, Adam J.; Yamaguchi, Dean J.; Goldberg, Emma J.; Iñigo, Melissa M.R.; Karnekar, Reema; Brophy, Patricia; Green, Thomas D.; Neufer, P. Darrell; Fisher-Wellman, Kelsey H.; Spangenburg, Espen E. (2020-09-17) -
Skeletal Muscle Undergoes Fiber Type Metabolic Switch Without Myosin Heavy Chain Switch in Response to Defective Fatty Acid Oxidation
Pereyra, Andrea S.; Lin, Chien-Te; Spangenburg, Espen E.; Neufer, P. Darrell; Fisher-Wellman, Kelsey; Ellis, Jessica M.; Sanchez, Daniela Mesa; Laskin, Julia (2022-02-09) -
Targeted Expression of Catalase to Mitochondria Protects Against Ischemic Myopathy in High-Fat Diet-Fed Mice
Spangenburg, Espen; Ryan, Terence E.; Schmidt, Cameron A.; Green, Thomas D.; Neufer, P. Darrell; McClung, Joseph M. (2016-06-09) -
Targeted Expression of Catalase to Mitochondria Protects Against Ischemic Myopathy in High-Fat Diet-Fed Mice
McClung, Joseph; Ryan, Terence E.; Schmidt, Cameron A.; Green, Thomas D.; Spangenburg, Espen E.; Neufer, P. Darrell (2016-06-09)