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Coronary Artery Ligation and Intramyocardial Injection in a Murine Model of Infarction
Mouse models are a valuable tool for studying acute injury and chronic remodeling of the myocardium in vivo. With the advent of genetic modifications to the whole organism or the myocardium and an array of biological and/or ...
Why Does Exercise â€œTriggerâ€? Adaptive Protective Responses in the Heart?
Numerous epidemiological studies suggest that individuals who exercise have decreased cardiac morbidity and mortality. Pre-clinical studies in animal models also find clear cardioprotective phenotypes in animals that ...
The â€œGoldilocks Zoneâ€? from a redox perspectiveâ€”Adaptive vs. deleterious responses to oxidative stress in striated muscle
Consequences of oxidative stress may be beneficial or detrimental in physiological systems. An organ system's position on the “hormetic curve” is governed by the source and temporality of reactive oxygen species (ROS) ...