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    Tulis, David A. (10)
    Durante, William (3)Peyton, Kelly J. (3)Joshi, Chintamani N. (2)Keswani, Amit N. (2)Liu, Xiao-Ming (2)Martin, Danielle N. (2)Mendelev, Natalia N. (2)Wang, Hong (2)Adderley, Shaquria P. (1)... View MoreSubjectCyclins (2)Neointima (2)YC-1 (2)AMPK (1)Apoptosis (1)Arginase (1)Balloon injury (1)BAY 41-2272 (1)cAMP (1)Carbon monoxide (1)... View MoreDate Issued2009 (4)2012 (3)2005 (1)2011 (1)Has File(s)true (10)

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    Arginase Promotes Neointima Formation in Rat Injured Carotid Arteries 

    Peyton, Kelly J.; Ensenat, Diana; Azam, Mohammad A.; Keswani, Amit N.; Kannan, Sankaranarayanan; Liu, Xiao-Ming; Wang, Hong; Tulis, David A.; Durante, William (East Carolina University, 2009-04)
    Objective—Arginase stimulates the proliferation of cultured vascular smooth muscle cells (VSMCs); however, the influence of arginase on VSMC growth in vivo is not known. This study investigated the impact of arginase on ...
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    Multiple Kinase Involvement in the Regulation of Vascular Growth 

    Adderley, Shaquria P.; Joshi, Chintamani N.; Martin, Danielle N.; Mooney, Shayna; Tulis, David A. (New York: InTech Open Access Publishers, 2012-06)
    The initial discovery of protein phosphorylation as a regulatory mechanism for the control of glycogen metabolism has led to intense interest of protein phosphorylation in regulating protein function (Cohen et al., 2001). ...
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    YC-1 Stimulates the Expression of Gaseous Monoxide-Generating Enzymes in Vascular Smooth Muscle Cells 

    Liu, Xiao-Ming; Peyton, Kelly J.; Mendelev, Natalia N.; Wang, Hong; Tulis, David A.; Durante, William (East Carolina University, 2009-01)
    The benzylindazole derivative 3-(5′-hydroxymethyl-2′-furyl)-1-benzyl indazole (YC-1) is an allosteric stimulator of soluble guanylate cyclase (sGC) that sensitizes the enzyme to the gaseous ligands carbon monoxide (CO) and ...
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    The cyclic GMP modulators YC-1 and zaprinast reduce vessel remodeling through anti-proliferative and pro-apoptotic effects 

    Keswani, Amit N.; Peyton, Kelly J.; Durante, William; Schafer, Andrew I.; Tulis, David A. (East Carolina University, 2009-06)
    Guanosine-specific cyclic nucleotide signaling is suggested to serve protective actions in the vasculature; however, the influence of selective pharmacologic modulation of cyclic guanosine monophosphate (GMP)-synthesizing ...
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    Anti-growth properties of BAY 41-2272 in vascular smooth muscle cells 

    Mendelev, Natalia N.; Williams, Verietta S.; Tulis, David A. (East Carolina University, 2009-02)
    Vascular smooth muscle (VSM) growth is integral in the pathophysiology of blood vessel diseases, and identifying approaches that have capacity to regulate VSM growth is critically essential. Cyclic nucleotide signaling has ...
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    Control of Vascular Smooth Muscle Cell Growth by Connexin 43 

    Joshi, Chintamani N.; Martin, Danielle N.; Shaver, Patti; Madamanchi, Chaitanya; Muller-Borer, Barbara J.; Tulis, David A. (2012-06)
    Connexin 43 (Cx43), the principal gap junction protein in vascular smooth muscle cells (VSMCs), regulates movement of ions and other signaling molecules through gap junction intercellular communication (GJIC) and plays ...
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    The Dopamine D3 Receptor Knockout Mouse Mimics Aging-Related Changes in Autonomic Function and Cardiac Fibrosis 

    Johnson, Tracy L.; Tulis, David A.; Keeler, Benjamin E.; Virag, Jitka A. I.; Lust, Robert M.; Clemens, Stefan (2013-)
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    Inhibition of vascular smooth muscle growth via signaling crosstalk between AMP-activated protein kinase and cAMP-dependent protein kinase 

    Stone, Joshua D.; Narine, Avinash; Tulis, David A. (2012-10)
    Abnormal vascular smooth muscle (VSM) growth is central in the pathophysiology of vascular disease yet fully effective therapies to curb this growth are lacking. Recent findings from our lab and others support growth control ...
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    LOCAL ADMINISTRATION OF CARBON MONOXIDE INHIBITS NEOINTIMA FORMATION IN BALLOON INJURED RAT CAROTID ARTERIES 

    Tulis, David A. (2005)
    Recent studies indicate that systemic induction of heme oxygenase-1 (HO-1), which oxidatively degrades heme into iron, biliverdin, and carbon monoxide (CO), or adenoviral-mediated gene transfer of HO-1 inhibits neointima ...
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    DINITROBENZENES STIMULATE ELECTRON FLUX WITHIN NEURONAL NITRIC OXIDE SYNTHASE IN THE ABSENCE OF CALMODULIN 

    Tulis, David A. (2011)
    Efficient electron transfer and conversion of L-arginine to L-citrulline and nitric oxide (NO●) by neuronal nitric oxide synthase (nNOS) requires calmodulin (CaM) binding. The present study focused on electron transfer ...

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