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MicroRNA-431 regulates axon regeneration in mature sensory neurons by targeting the Wnt antagonist
(2013-10)
MicroRNAs (miRNAs) are small, non-coding RNAs that function as key post-transcriptional regulators in neural development, brain function, and neurological diseases. Growing evidence indicates that miRNAs are also important ...
DINITROBENZENES STIMULATE ELECTRON FLUX WITHIN NEURONAL NITRIC OXIDE SYNTHASE IN THE ABSENCE OF CALMODULIN
(2011)
Efficient electron transfer and conversion of L-arginine to L-citrulline and nitric oxide
(NO●) by neuronal nitric oxide synthase (nNOS) requires calmodulin (CaM) binding. The
present study focused on electron transfer ...
Molecular mechanisms of peripheral nerve regeneration: emerging roles of microRNAs
(2013-02)
MicroRNAs are small non-coding RNAs that suppress gene expression through target mRNA degradation or translation repression. Recent studies suggest that miRNA plays an important role in multiple physiological and pathological ...
Essential role of proteasomes in maintaining self-renewal in neural progenitor cells
(2016-01)
Protein turnover and homeostasis are regulated by the proteasomal system, which is critical for cell function and viability. Pluripotency of stem cells also relies on normal proteasomal activity that mitigates senescent ...
Why Does Exercise “Trigger� Adaptive Protective Responses in the Heart?
(2015-05)
Numerous epidemiological studies suggest that individuals who exercise have decreased cardiac morbidity and mortality. Pre-clinical studies in animal models also find clear cardioprotective phenotypes in animals that ...
Control of Vascular Smooth Muscle Cell Growth by Connexin 43
(2012-06)
Connexin 43 (Cx43), the principal gap junction protein in vascular smooth muscle cells (VSMCs), regulates movement of ions and other signaling molecules through gap junction intercellular communication (GJIC) and plays ...
Enhanced Mitochondrial Superoxide Scavenging Does Not Improve Muscle Insulin Action in the High Fat-Fed Mouse
(2015-05)
Improving mitochondrial oxidant scavenging may be a viable strategy for the treatment of insulin resistance and diabetes. Mice overexpressing the mitochondrial matrix isoform of superoxide dismutase (sod2tg mice) and/or ...
Vasodilator-stimulated phosphoprotein regulates arterial smooth muscle cell migration
(East Carolina University, 2016-09-08)
Cardiovascular disease (CVD) is a multi-faceted pathology that remains the number one killer of all Americans and people worldwide. Vascular inflammation, endothelial dysfunction, extracellular matrix imbalance, and arterial ...
Cardiovascular Outcomes Following Xenobiotic Pulmonary Exposures
(East Carolina University, 2017-07-06)
Cardiovascular disease remains the leading cause of mortality in the developed world. Over the past decades, investigations have demonstrated that pulmonary exposure to xenobiotic particulate matter promotes and exacerbates ...