Browsing College of Allied Health Sciences by Author "Jones, Sherri M."

Now showing items 1-12 of 12

  • Characterization of Vestibular Dysfunction in the Mouse Model for Usher Syndrome 1F 

    Alagramam, Kumar N.; Stahl, John S.; Jones, Sherri M.; Pawlowski, Karen S.; Wright, Charles G. (East Carolina University, 2005-06)
    The deaf-circling Ames waltzer (av) mouse harbors a mutation in the protocadherin 15 (Pcdh15) gene and is a model for inner ear defects associated with Usher syndrome type 1F. Earlier studies showed altered cochlear hair ...

  • A comparison of vestibular and auditory phenotypes in inbred mouse strains 

    Jones, Sherri M.; Jones, Timothy A.; Johnson, Kenneth R.; Yu, Heping; Erway, Lawrence C.; Zheng, Qing Y. (East Carolina University, 2006-05-26)
    The purposes of this research were to quantify gravity receptor function in inbred mouse strains and compare vestibular and auditory function for strain- and age-matched animals. Vestibular evoked potentials (VsEPs) were ...

  • Functional Aging of the Inner Ear Sensory Systems in Mouse Models of Age-Related Hearing Loss 

    Mock, Bruce Elliott (East Carolina University, 2009)
    Age related structural and functional change in the cochlea have been well described and predisposing factors including genetic background, gender, and environmental factors have been identified. To date, nine genetic loci ...

  • Insights Into Elevated Distortion Product Otoacoustic Emissions In Sickle Cell Disease: Comparisons of Hydroxyurea-treated and Non-treated Young Children 

    Stuart, Andrew; Jones, Sherri M. (East Carolina University, 2006)
    Distortion product otoacoustic emissions (DPOAEs) were examined in 15 normal- hearing African-American children between the ages of 6 and 14 years with homozygous sickle cell disease (SCD), who were on a regimen of hydroxyurea ...

  • Orphan Glutamate Receptor delta-1 Subunit Required for High-Frequency Hearing 

    Gao, Jiangang; Maison, Stephane F.; Wu, Xudong; Hirose, Keiko; Jones, Sherri M.; Bayazitov, Ildar; Tian, Yong; Mittleman, Guy; Matthews, Douglas B.; Zakharenko, Stanislav S.; Liberman, M. Charles; Zuo, Jian (East Carolina University, 2007-06)
    The function of the orphan glutamate receptor delta subunits (GluR 1 and GluR 2) remains unclear. GluR 2 is expressed exclusively in the Purkinje cells of the cerebellum, and GluR 1 is prominently expressed in inner ear ...

  • Osteopontin is not Critical for Otoconia Formation or Balance Function 

    Zhao, Xing; Jones, Sherri M.; Thoreson, Wallace B.; Lundberg, Yunxia Wang (East Carolina University, 2008-06)
    Unlike the structural and mechanical role of bone crystals, the inertial mass of otoconia crystals provides a shearing force to stimulate the mechanoreceptors of the utricle and saccule (the gravity receptor organ)under ...

  • Otoconin-90 Deletion Leads to Imbalance but Normal Hearing: A Comparison with Other Otoconia Mutants 

    Zhao, X.; Jones, Sherri M.; Yamoah, E. N.; Lundberg, Yunxia Wang (East Carolina University, 2008-04)
    Our sense of gravitation and linear acceleration is mediated by stimulation of vestibular hair cells through displacement of otoconia in the utricle and saccule (the gravity receptor organ). We recently showed that otoconin-90 ...

  • A Quantitative Survey of Gravity Receptor Function in Mutant Mouse Strains 

    Jones, Sherri M.; Johnson, Kenneth R.; Yu, Heping; Erway, Lawrence C.; Alagramam, Kumar N.; Pollak, Natasha; Jones, Timothy A. (East Carolina University, 2005-12)
    The purpose of this research was to identify vestibular deficits in mice using linear vestibular evoked potentials (VsEPs). VsEP thresholds, peak latencies, and peak amplitudes from 24 strains with known genetic mutations ...

  • Resting Discharge Patterns of Macular Primary Afferents in Otoconia-Deficient Mice 

    Jones, Timothy A.; Jones, Sherri M.; Hoffman, L. F. (East Carolina University, 2008-12)
    Vestibular primary afferents in the normal mammal are spontaneously active. The consensus hypothesis states that such discharge patterns are independent of stimulation and depend instead on excitation by vestibular hair ...

  • Structural aging of the utricular macula in mice 

    Pierce, Jessica (East Carolina University, 2012)
    CBA/CaJ is a mouse strain that has no known genetic mutations affecting the inner ear, thereby serving as a control model for auditory and vestibular aging. C57BL/6J and CE/J mouse strains carry the genetic mutation ...

  • A targeted Coch missense mutation: a knock-in mouse model for DFNA9 late-onset hearing loss and vestibular dysfunction 

    Robertson, Nahid G.; Jones, Sherri M.; Sivakumaran, Theru A.; Giersch, Anne B. S.; Jurado, Sara A.; Call, Linda M.; Miller, Constance E.; Maison, Stephane F.; Liberman, M. Charles; Morton, Cynthia C. (East Carolina University, 2008-11-01)
    Mutations in COCH (coagulation factor C homology) are etiologic for the late-onset, progressive, sensorineural hearing loss and vestibular dysfunction known as DFNA9. We introduced the G88E mutation by gene targeting into ...

  • Vestibular function following blast injury 

    Mills, Kristal N. (East Carolina University, 2011)
    To date, the war on terror has produced over 30,000 wounded military personnel with a large proportions of injuries attributed to blasts. Dizziness and imbalance are common complaints among the blast-injured population. ...