Browsing Dissertations and Theses by Title
Now showing items 2406-2425 of 4831
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Investigation of Curli-Specific Proteins CsgD and CsgA Reveals a Potential Target for Neurodegenerative Therapeutics and Provides Structural Insights into the Bacterial Amyloid CsgA
(East Carolina University, 2022-12-06)A growing body of evidence implicates curli-containing biofilms in the onset of neurodegenerative pathologies like Alzheimer’s and Parkinson’s diseases. Curli-containing biofilms are composed primarily of two bacterial ... -
Investigation of Molecular Mechanism of Transthyretin Oligomerization Associated with ATTR Amyloidosis
(East Carolina University, 2022-04-27)Transthyretin amyloidosis (ATTR) has classically been diagnosed predominantly post-observation of amyloid fibril deposition on soft tissues within the body, however, recent studies have shown that oligomers which arise ... -
Investigation of NADPH-Dependent Thioredoxin Reductase-C (NTRC) In Chloroplast Lipid Metabolism
(East Carolina University, 2022-07-01)Redox reactions are ubiquitous within plant metabolism and critical for the sustainment of photosynthesis within thylakoid membranes. Specialized glycerolipids that make up these membranes in turn require redox reactions ... -
Investigation of NADPH-Dependent Thioredoxin Reductase-C (NTRC) In Chloroplast Lipid Metabolism
(East Carolina University, 2022-07-01)Redox reactions are ubiquitous within plant metabolism and critical for the sustainment of photosynthesis within thylakoid membranes. Specialized glycerolipids that make up these membranes in turn require redox reactions ... -
Investigation of Nonhydrolyzable ATP Analogues and Cofilin-Derived Peptides for Inhibition of Cofilin-Actin Rod Formation
(East Carolina University, 2021-08-02)Actin-Cofilin rods are an important marker of neurodegenerative disease and are commonly observed in the neurons of patients with Alzheimer's disease. The goal of this research is to investigate peptide and small-molecules ... -
Investigation of Platinum-Catalyzed Acylation of 2-Aryloxypyridines via C-H Activation and Functionalization
(East Carolina University, 2022-07-12)Transition metal catalyzed C-H activation and functionalization reactions allow synthetic chemists to break the normally unreactive carbon-hydrogen bond and create a new and useful carbon-oxygen, carbon-nitrogen, carbon-halogen, ... -
Investigation of Platinum-Catalyzed Acylation of 2-Aryloxypyridines via C-H Activation and Functionalization
(East Carolina University, 2022-07-12)Transition metal catalyzed C-H activation and functionalization reactions allow synthetic chemists to break the normally unreactive carbon-hydrogen bond and create a new and useful carbon-oxygen, carbon-nitrogen, carbon-halogen, ... -
Investigation of possible driving forces on counter-intuitive thermal collapse of intrinsically disordered proteins
(East Carolina University, 2016-08-18)Intrinsically disordered proteins are an emerging class of proteins that contain no secondary or tertiary structure. Through bioinformatics studies it has been predicted that a third of the human proteome consists of ... -
Investigation of Safety Culture among Young Workers
(East Carolina University, 2019-04-30)According to the Occupational Safety and Health Administration (OSHA), young workers whose ages range from 14 to 24 and are interested in finding different jobs during the summer or during the school year are considered ... -
Investigation of the Anatomical and Physiological Changes Following the Use of a Pedicled Buccal Fat Pad Graft During Primary Palatoplasty
(East Carolina University, 2019-07-19)Children with cleft palate typically undergo primary surgery between 6-12 months of age to close the cleft in the palate and create proper muscle function for elevation and retraction of the velum for speech. About one ... -
AN INVESTIGATION OF THE TAPHONOMIC EFFECTS OF ANIMAL SCAVENGING
(East Carolina University, 2014)Numerous environmental and human-induced variables that affect decomposition can cloud accurate estimations of the postmortem interval (PMI). For instance, scavenging animals can remove soft tissue and disarticulate and ... -
Investigation of the Zinc binding region of Prothymosin-alpha : A spectroscopic and thermodynamic approach to study metal binding in Intrinsically disordered proteins
(East Carolina University, 2014)The goal of this study is to provide a deeper insight into how metals bind intrinsically disordered proteins (IDPs) by taking zinc binding to prothymosin-alpha as a case study. The involvement of metals in several diseases ... -
Investigations into the Oldest Standing Structure in North Carolina
(East Carolina University, 1/13/16)In 2010, Steven and Linda Lane purchased 304 East Queen Street, Edenton, North Carolina. While renovating the structure they discovered that it was much older than previously thought. The results of a dendrochronology ... -
Investigations into the roles of bacteroides fragilis thioredoxins during the oxidative stress response
(East Carolina University, 2011)The Gram-negative Bacteroides fragilis is the most frequently isolated bacterium from anaerobic infections. Native to the human intestinal tract, it serves a symbiotic role breaking down complex polysaccharides and ... -
Investigations of the Brevard Fault zone and Tugaloo Terrane adjacent to the Grandfather Mountain Window, North Carolina
(East Carolina University, 2023-07-24)The Brevard Fault Zone adjacent to the Grandfather Mountain window, NC is interpreted to be a terrane boundary between Laurentian margin rocks and accreted rocks of the Tugaloo Terrane. Structural, geochemical, and ... -
The involvement of cap-independent mRNA translation in cell fate decisions
(East Carolina University, 2014)During cell stress many biochemical processes are shut down. For example, global mRNA translation initiation is inhibited due to the disruption of the cap-dependent mRNA recruitment mechanism. One specific example of ...