Increasingly, reactive oxygen species (ROS) are implicated in the development of insulin resistance. To test the hypothesis that modulators of insulin sensitivity (i.e., metformin, ovarian sex steroids and exercise training) ...

Multiple proteins are involved in the complete and accurate replication of the genome during S phase of the cell cycle. At the G1/S phase transition, the heterotetrameric GINS complex is recruited to the origin, and ...

In eukaryotic cells, DNA replication and the subsequent packaging of DNA into specific chromatin states are essential processes for the transmission of genetic material and genomic stability which may be linked by interactions ...

In Western countries, breast cancer is the most common form of cancer and it is the second leading cause of female cancer death in America. The biochemical basis of the observed anti-oncogenic properties of green tea has ...

The cell membrane protects the delicate internal machinery of the cell and hosts a complex transport system for ion exchange with the environment. Energy is continually expended to maintain a transmembrane electrical ...

CD44 is an adhesion molecule involved in several biological functions and the primary receptor for hyaluronan (HA). In cartilage, CD44 participates in the interplay between cells and the extracellular matrix to fine tune ...

Tumor vascularization is an important control point in cancer progression and its inhibition is a promising approach to cancer therapy. Stromal-derived factor-1 alpha (SDF-1 alpha or CXCL12) is a chemoattractant for ...

Sld5 is one component of the GINS heterotetrameric complex essential to DNA replication. Specifically, GINS is known for its integral role during the G1 to S phase transition in the cell cycle. The GINS complex is comprised ...