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Metabolic Inflexibility in Response to Lipid Oversupply with Obesity: Epigenetic Modifications Play a Role
(East Carolina University, 2013)
The ability to adjust substrate oxidation according to nutrient availability has been termed `metabolic flexibility' and is a critical factor in overall metabolic health. In respect to fatty acid oxidation (FAO) metabolic ...
Effects of a mentor-led exercise intervention on physical self-perceptions, fitness, body composition, and physical activity of overweight adolescents
(East Carolina University, 2013)
In recent decades, the prevalence of youth obesity has been on the rise (Ogden et al, 2010) highlighting the need for research evaluating interventions targeting eating behaviors and lifestyle activity. Although it is ...
High-Fat Diet Induced Obesity Increases Serum Myostatin, but Does Not Accelerate Skeletal Muscle Atrophy
(East Carolina University, 2013)
Myostatin is a potent negative regulator of muscle mass, i.e. high levels of myostatin induce loss of muscle. Surprisingly, severely obese humans and obese mice have elevated levels of serum myostatin, but the role of ...
EFFECTS OF MODERATE AEROBIC EXERCISE ON THE ATTENUATION OF LEAN MASS LOSS DURING RAPID WEIGHT LOSS
(East Carolina University, 2013)
Background: Obesity has become a severe issue in the United States, and gastric bypass surgery has been one of the most successful tools to combat the adverse consequences of this disease. The rapid weight loss associated ...
EFFECTS OF A 16 WEEK PHYSICAL ACTIVITY INTERVENTION ON SERUM C-REACTIVE PROTEIN CONCENTRATIONS IN 8-11 YEAR OLD AFRICAN AMERICAN AND CAUCASIAN CHILDREN.
(East Carolina University, 2013)
C-reactive protein (CRP) is a non-specific marker of systemic inflammation that has been associated with heart disease, obesity, and metabolic disorders in adults and children. Previous physical activity interventions have ...
Training and Endothelial Function In Upper and Lower Limbs
(East Carolina University, 2013)
Cardiovascular disease (CVD) begins with damage to the endothelium, the inner lining of the blood vessels. Endothelial damage occurs as early as childhood and is associated with risk factors such as obesity, hypertension, ...
The Effect of Plantarflexor Strength Training on Gait Biomechanics in Healthy Old Adults
(East Carolina University, 2013)
Locomotion is an important and inherent part of daily life and is integral in maintaining an independent lifestyle, especially in older adults whose functional capacity has declined. Physiological changes with aging, ...
Development of Walk Tests to Estimate Aerobic Fitness in 10 to 13 Year-Old Children
(East Carolina University, 2013)
Aerobic fitness is an important indicator of health for children. Estimation of aerobic fitness (VO₂[subscript]max) from field-based tests is an essential aspect of youth fitness tests. Field tests can also provide researchers ...
The Effects of Quadriceps Strengthening Exercise on Quadriceps Muscle Biomechanics During Locomotion in Adults with Knee Osteoarthritis
(East Carolina University, 2013)
Knee Osteoarthritis (OA) is a disease characterized by knee joint deterioration and pain, while also being associated with altered knee joint mechanics and quadriceps strength deficits. Research investigating the effects ...
Proximal vs. Distal Fascicle Behavior within the Biceps Femoris Long Head at Different Muscle Activation Levels
(East Carolina University, 2013)
Hamstring strains have been shown to occur more often in the long head of the biceps femoris (BFLH) than the semitendinosus and semimembranosus, with most injuries occurring in the proximal half of the BFLH. Muscle modeling ...