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The role of the proximal small intestine in improvements in diabetes resolution and insulin sensitivity following bariatric surgery in type 2 diabetes
(East Carolina University, 2011)
Bariatric surgery is an effective, rapid, and durable treatment for obesity and type 2 diabetes mellitus (T2DM). Roux-en Y Gastric Bypass (RYGB) resolves T2DM in 80% of cases, while gastric banding (LAGB) resolves T2DM in ...
Cleaved Caspase-3 Response to Acute Resistance Exercise in Young and Old Men and Women : Relationship to Muscle Glycogen Content and 5'-AMP-Activated Protein Kinase (AMPK) Activity
(East Carolina University, 2011)
In addition to suppressing protein synthesis and activating protein degradation in skeletal muscle and other cell types, 5'-AMP-activated protein kinase (AMPK) is known to stimulate nuclear apoptosis in non-muscle cells ...
The Physiological and Pathological Role of Mitochondrial Calcium in the Diabetic Heart
(East Carolina University, 2011)
Diabetic patients are more susceptible to ischemia/reperfusion injury and cardiac dysfunction likely due alterations in mitochondrial calcium handling. The purpose of this work was to determine if redox-dependent changes ...
THE ROLE OF LONG-CHAIN ACYL-COENZYME A SYNTHETASE 1 (ACSL-1) IN LIPID METABOLISM IN HUMAN SKELETAL MUSCLE PRIMARY MYOTUBES.
(East Carolina University, 2011)
Obesity is considered a major health threat to the U.S. due to being a strong risk factor for developing type 2 diabetes and other metabolic diseases. The prevalence and severity of obesity is even greater among some ...
The Influence of Energy Expenditure on Mitochondrial Functions, Oxidative Stress and Insulin Resistance under Metabolic Oversupply Conditions
(East Carolina University, 2011)
Mitochondrial respiratory capacity and oxidative stress have been implicated in the development of insulin resistance (IR) and type II diabetes. A causative role of mitochondrial oxidative stress in the etiology of ...
Effects of Dietary Leucine Supplementation on Muscle Mass and Markers of Protein Degradation in Overloaded Skeletal Muscles of Young Adult and Aged Rats
(East Carolina University, 2011)
The hypertrophic response to overload in fast-twitch skeletal muscle is impaired in aged humans and rats, and upregulation of protein degradation pathways are hypothesized to be a contributing factor. Muscle growth occurs ...
Effect of MicroRNA-34c on Regenerative Axon Growth in Dorsal Root Ganglion Neurons of the Peripheral Nervous System
(East Carolina University, 2011)
The peripheral nervous system is unique in its ability to regenerate axons after injury. Our lab previously assessed the miRNA expression levels of the regenerating sciatic nerve which indicated miR-34c up-regulation. ...