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The role of mediators of neuronal plasticity in the circadian regulation of suprachiasmatic nucleus by light
(East Carolina University, 2009)
Circadian rhythms are highly conserved physiological functions that are present in almost all living organisms. In mammals, circadian rhythms are synchronized to the environmental light:dark cycle by daily adjustments in ...
SKELETAL MUSCLE INSULIN SENSITIVITY AND DURATION OF TYPE 2 DIABETES MELLITUS
(East Carolina University, 2012)
Type 2 Diabetes Mellitus (T2DM) resolution following Roux-en Y gastric bypass (RYGB) surgery is reduced in patients with longer duration of T2DM and preliminary data suggest this may be mechanistically linked to lower ...
The role of the proximal small intestine in improvements in diabetes resolution and insulin sensitivity following bariatric surgery in type 2 diabetes
(East Carolina University, 2011)
Bariatric surgery is an effective, rapid, and durable treatment for obesity and type 2 diabetes mellitus (T2DM). Roux-en Y Gastric Bypass (RYGB) resolves T2DM in 80% of cases, while gastric banding (LAGB) resolves T2DM in ...
The Effect of Concept Mapping on Student Understanding and Correlation with Student Learning Styles
(East Carolina University, 2013)
This study investigated the use of concept mapping as a pedagogical strategy to promote change in the learning styles of pre-nursing students. Students' individual learning styles revealed two subsets of students; those ...
Effects of Aerobic Capacity Phenotype on Adaptive Responses to Ischemic Stress
(East Carolina University, 2009)
Ischemic disease leads to increased tissue stress by decreasing supply of nutrients adequate to meet energy demands. To maintain functionality, compensatory mechanisms for diminished vascular supply are induced by numerous ...
NADPH Oxidase as a Mechanistic Link Between Erectile Dysfunction, Peripheral, and Coronary Endothelial Dysfunction in Obesity
(East Carolina University, 2012)
Cardiovascular complications involving both microvascular and macrovascular tissues are the major cause of morbidity and mortality in obese patients. Clinical and epidemiological studies suggest that erectile dysfunction ...
Measured Resting Energy Expenditure Using a Fixed Function Indirect Calorimeter in the Clinical Setting as a Predictor of Success with Weight Change in an Obese Pediatric Population
(East Carolina University, 2010)
The American Dietetic Association (ADA) standard of care for obese adults utilizes indirect calorimetry for calculating caloric targets for weight loss (1). Even though rates appear to be leveling off (2), childhood obesity ...
Augmented coronary vascular smooth muscle response to endothelin-1 exacerbates cardiac injury following pulmonary exposure to engineered nanomaterials
(East Carolina University, 2014)
Multi-walled carbon nanotubes (MWCNT) and 60-carbon fullerenes (C60) are important engineered nanoparticles (ENP) used across industry. Exposure to ENP potentially promotes cardiovascular detriments. The hypotheses that ...
The induction of antigen-specific immunological tolerance and attenuation of inflammation via cytokine antigen fusion protein therapy in a mouse model of pulmonary inflammation
(East Carolina University, 2014)
Allergic asthma is a significant medical issue, affecting more than 300 million individuals and causing approximately 250,000 deaths each year. Current asthma therapies temporarily minimize discomfort and manage symptoms, ...
Cleaved Caspase-3 Response to Acute Resistance Exercise in Young and Old Men and Women : Relationship to Muscle Glycogen Content and 5'-AMP-Activated Protein Kinase (AMPK) Activity
(East Carolina University, 2011)
In addition to suppressing protein synthesis and activating protein degradation in skeletal muscle and other cell types, 5'-AMP-activated protein kinase (AMPK) is known to stimulate nuclear apoptosis in non-muscle cells ...