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Assessing the Risk of IADL Tasks from the Perspective of Medically-at-risk Older Adults and their Caregivers
(East Carolina University, 2009)
The purpose of this study was to was to understand the impact of chronic disease on the functional ability of older adults by determining which instrumental activities of dialing living (IADL) are most meaningful and may ...
A Study of Division Deans' in the North Carolina Community College System Self Perceived Leadership Style Based on Bolman and Deal's Four Frame Theory
(East Carolina University, 2008)
This study was designed to expand the knowledge base of academic division deans by correlating differences in leadership styles (i.e., frames) of the division deans within the North Carolina Community College System. The ...
"...And all the men knew the colors of the sea..." : historical and archaeological investigation of the SS Commodore, Ponce Inlet, Florida
(East Carolina University, 2005)
This study focuses on a single question: Are the wreck site remains held under joint title by the Ponce Inlet Lighthouse Association and Norman Serbousek those of the SS Commodore, sunk on January 1, 1897? The answer to ...
The unique roles of IFE-1, a germline-specific isoform of eukaryotic translation factor 4E, during gametogenesis
(East Carolina University, 2009)
Fertility and embryonic viability are measures of efficient germ cell growth and differentiation. During oogenesis, spermatogenesis and embryogenesis cells initially proliferate then differentiate into specific tissues. New proteins are required for both cell growth and differentiation, requiring qualitative and quantitative changes in protein synthesis. During late gametogenesis and early embryogenesis the expression of the appropriate proteins is a primarily due to translational control. Translational control of mRNAs is mediated in part by eukaryotic initiation factor 4E (eIF4E). eIF4E binds the methylated 5' cap of mRNA and recruits it to the ribosome. The nematode worm C.elegans expresses five isoforms of eIF4E (termed IFE-1 through 5). IFE-1 is expressed primarily in the germline and is the only isoform that associates with P granules by binding directly to PGL-1. P granules are ribonucleoprotein particles (RNPs) that contain stored mRNAs and proteins needed for oogenesis and early embryogenesis. Using a strain that lacks IFE-1, I assessed the translational efficiency of maternal mRNAs bound and not bound to P granules by polysome fractionation. Translation of pos-1, pal-1, mex-1, oma-1, ced-4 and glp-1 mRNAs was inefficient in the ife-1 strain relative to wild type worms. GAPDH (gpd-3) mRNA translation was not affected. We also observed differences in the pattern of expression of the MEX-1 protein during oogenesis. In males, secondary spermatocytes failed to complete cytokinesis at 25°C in absence of IFE-1. Males deficient of IFE-1 therefore lacked mature sperm. In addition, ife-1 spermatocytes prematurely accumulated pro-apoptotic CED-4, homolog to mammalian Apaf-1, during spermatogenesis. In ife-1 worms fertility was decreased by 80% due to decreased viability of both oocytes and spermatocytes. Our data indicate two unique roles for eIF4E (IFE-1 isoform) in late oogenesis and spermatogenesis. We suggest that IFE-1 preferentially recruits regulated mRNAs at critical times during germ cell development. ...
"A Fair Specimen of a Southern River Steamer": The Oregon and Tar/Pamlico River Steam Navigation
(2003-05)
Steam navigation began successfully on North Carolina's Cape Fear River in 1818 and within a decade all of North Carolina's rivers hosted steamers, except for the Tar/Pamlico River. The Tar/Pamlico River lagged behind other ...
A MULTIVARIATE APPROACH TO ESTABLISH HABITAT CLASSIFICATIONS IN A CORAL REEF ECOSYSTEM USING LANDSAT 7 SATELLITE IMAGERY AT TURNEFFE A TOLL, BELIZE, CENTRAL AMERICA.
(2004-03)
The use of multivariate cluster and discriminant function analysis of ground truth data
and LANDSAT 7 satellite imagery (23 May 2000) was examined to classify tropical
marine habitats at Tumeffe Atoll, Belize. Ground ...
FROM NEW BERN TO BENNETT PLACE WITH "COOKE'S FOOT" CAVALRY: A HISTORY OF THE TWENTY-SEVENTH REGIMENT OF NORTH CAROLINA TROOPS, 1861-1865
(2007-09-01)
The purpose of this thesis is to examine the history of the Twenty-Seventh North
Carolina regiment and the actions of its officers and men during the American Civil War. This regiment was often in the forefront of Confederate ...
The Biochemical Characterization Of Neuronal K+ Channel N-Glycans And Their Role In Regulating K+ Channel Function
(East Carolina University, 2009)
The Kv3 and Kv1 subfamilies of voltage–gated K+ channels are critical components which contribute to action potential repolarization throughout the central nervous system. Here, it was shown that both absolutely conserved ...
Priming Anxiety into People who Stutter: Arousal's Influence on Fluency
(East Carolina University, 2008-11)
Many experimental psychologists (Bargh, Chen & Burrows, 1996; Berner & Maier, 2004; Bowers, 1999; Chartrand, VanBaaren & Bargh, 2006; Chen & Haviland-Jones, 2000; Hazlett, Dawson, Schell & Filion, 1990; Macky-Sim & Laing, ...
The Effects of Social Stories on Language and Social Appropriateness in Children with Autism Spectrum Disorders
(East Carolina University, 2009)
This study employed a single-subject design to determine the effects of Social Stories<super>TM</super> treatment approach on the language and social skills, specifically turn-taking, of four children with autism spectrum ...