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Effects of obesity on the transcriptional regulation of protein degradation in skeletal muscle
(East Carolina University, 2013)
Effects of obesity on the transcriptional regulation of protein degradation in skeletal muscle by Lance M. Bollinger November, 2013 Director of Thesis/Dissertation: Jeffrey J. Brault Major Department: Kinesiology ...
Adenosine monophosphate-activated protein kinase inhibits vascular smooth muscle growth associated with vasculoproliferative disorders
(East Carolina University, 2013)
Vascular growth disorders are the major contributing factor to cardiovascular disease, the leading cause of morbidity and mortality worldwide. Aberrant vascular smooth muscle cell (VSMC) growth is a primary etiology ...
Metabolic, Physiological, And Behavioral Responses Of Prey To Predation
(East Carolina University, 2015)
Predators are known to cause prey to alter their morphology, life history or behavior in ways that reduce the likelihood of the prey being consumed by the predator. Seldom considered, however, are the consequences of ...
Effects Of Extracellular Matrix Stiffness On Muscle Fiber Mechanotransduction Signaling In Aged Rats
(East Carolina University, 2015)
The loss of muscle mass with age, termed sarcopenia, is a common problem among the over 60 years-old population. Resistance training is often prescribed as treatment, but older adults have shown a reduced response to ...
G Protein-Coupled Receptor Signaling in Growth and Inflammation of Vascular Smooth Muscle
(East Carolina University, 2021-06-22)
Cardiovascular disease (CVD) remains the primary cause of morbidity and mortality in the United States and worldwide. The exaggerated release of serine proteases and reduced blood flow and ensuing development of extracellular ...
Paternal diet and exercise epigenetically program energy expenditure and glucose metabolism in mouse offspring
(East Carolina University, 2014)
It is currently estimated that a third of Americans suffer from metabolic syndrome, which is an obesogenic disease shown to increase risk for developing type 2 diabetes (T2DM) by five-fold (Diabetes Care, 2012). The ...
NOVEL MECHANISMS GOVERNING SKELETAL MUSCLE MITOCHONDRIAL BIOENERGETICS : OXPHOS EFFICIENCY AND cAMP/PKA SIGNALING
(East Carolina University, 2014)
Understanding the regulation of cellular metabolism is paramount to treating the growing prevalence of metabolic disease worldwide. In cellular metabolism, mitochondrial oxidative phosphorylation (OXPHOS) plays a key role ...
Targeting the mitochondrial inner membrane to improve bioenergetics in the diseased heart
(East Carolina University, 2014)
Cardiovascular diseases continue to exact unparalleled economic and humanitarian costs across the globe. Manifestations of cardiovascular diseases include acute coronary syndromes and heart failure, both of which are ...
Tissue Salvage in the Non-reperfused Myocardium Mediated by (the absence of the circadian rhythm gene) mPer2 and (the receptor tyrosine kinase) EphrinA1
(East Carolina University, 2010)
Alterations in circadian rhythm have been associated with numerous cardiovascular pathologies. In project 1, we tested the hypothesis that functional mutation of the Per2 circadian clock gene would provide cardioprotection ...
Intratracheal instillation of silver nanoparticles exacerbates cardiac ischemia/reperfusion injury in male sprague-dawley rats
(East Carolina University, 2014)
The uses of engineered nanomaterials have expanded in biomedical technology and consumer manufacturing. Exposure to particulate matter has been demonstrated to negatively influence cardiovascular health and expand myocardial ...