Browsing Dissertations by Title
Now showing items 616-635 of 1044
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Modulation of experimental autoimmune myocarditis with cytokine-myosin fusion proteins and novel cardiac peptides
(2016-05-16)Infectious agents that induce cross-reactive myocarditic T cell responses may cause autoimmune inflammation of the heart, dilated cardiomyopathy (DCM), and heart failure. The purpose of this study was to evaluate the ... -
Modulation of IKKβ with AMPK Improves Insulin Sensitivity in Skeletal Muscle
(East Carolina University, 2008-11)Activation of the insulin receptor substrate (IRS)-1 is necessary for proper transduction of the insulin signal. IRS-1 serine312(human)/307(rodent) phosphorylation, however, results in disruption of this signal and subsequent ... -
Molecular characterization of the activation domain of the HTLV-1 HBZ protein and its interaction with the KIX domain of the cellular transcriptional coactivators p300 and CBP
(East Carolina University, 2010)The complex retrovirus human T-cell leukemia virus type I (HTLV-1) is the causative agent of adult T-cell leukemia (ATL). Deregulation of cellular transcription is thought to be a key event in virally-mediated T-cell ... -
Molecular evolution of venom proteins in Ctenidae (Order: Araneae) spiders
(East Carolina University, 2021-01-20)Spiders comprise the largest group of venomous animals and are a pivotal component of the global ecosystem with approximately 50,000 species spread across nearly every habitat on Earth. The family Ctenidae Keyserling, 1877 ... -
Molecular mechanism of anandamide-induced apoptosis in non-melanoma skin cancer.
(East Carolina University, 2015)Non-melanoma skin cancer (NMSC) is the most common cancer in the United States. The absence of selective toxicity is the major problem associated with chemotherapeutic and radiation therapy for NMSCs. The goal of the present ... -
MOLECULAR MECHANISM OF ELLAGIC ACID AND UROLITHIN A IN THE SUPPRESSION OF PROSTATE CANCER BY INFLUENCING THE p53-MDM2 PATHWAY
(East Carolina University, 2019-07-10)Carcinoma of the prostate (CaP) is the most common cancer in men and the second leading cause of cancer-related death in men worldwide. Despite the available treatments for CaP including surgery and Androgen deprivation ... -
MOLECULAR MECHANISM OF THE CYTOTOXIC AND IMMUNOSTIMULATORY ACTIVITY OF 15 DEOXY PROSTAMIDE J2: INVESTIGATION OF CHOP10 AND NFĸB SIGNALING IN COLON CANCER
(East Carolina University, 2019-08-13)The endoplasmic reticulum (ER) stress pathway is a prominent regulator of cancer cell death and as a result, ER stress inducers are being exploited pharmacologically. Cytotoxic ER stress is typically regulated by the ... -
Molecular Mechanisms of Peripheral N-Methyl-D-Aspartate Mediated Pressor Response
(East Carolina University, 2012)The primary goal of this study was to characterize the N-Methyl-D-Aspartate (NMDA) receptor within the cardiovascular system and elucidate the molecular mechanisms involved in peripheral NMDA receptor-mediated pressor ... -
Molecular mechanisms of TMEFF2 action in Prostate Cancer
(East Carolina University, 2013)The transmembrane protein with epidermal growth factor and two follistatin motifs 2 (TMEFF2) is an evolutionarily conserved type I transmembrane protein expressed in the embryo and limited adult tissues, mainly the brain ... -
Molecular Mechanisms Underlying Cannabidiol-Improved Vocal Recovery Following Damage to a Songbird Vocal Pre-Motor Cortical-Like Region
(East Carolina University, 2023-04-27)The non-euphorigenic phytocannabinoid CBD has been found to be effective in treating childhood-onset epilepsies, conditions that are often associated with developmental delays, including vocal communication. Zebra finch ... -
Motility and chemotaxis in the Lyme disease spirochete Borrelia burgdorferi : role in pathogenesis
(East Carolina University, 2016-08-18)Lyme disease is the most prevalent vector-borne disease in United States and is caused by the spirochete Borrelia burgdorferi. The disease is transmitted from an infected Ixodes scapularis tick to a mammalian host. B. ... -
MOVING FROM THE MIDDLE: AN EXPLORATION OF STUDENT EXPERIENCES TRANSITIONING TO HIGH SCHOOL IN INTERNATIONAL SETTINGS
(East Carolina University, 2019-04-12)The current study sought to understand the stress of the eighth grade to high school transition at the International School Bangkok (ISB) and make recommendations for improving this experience. Transitioning from middle ... -
Multidimensional Conceptualization and Assessment of Fatigue in Pediatric Sickle Cell Disease: Impact of Fatigue on Quality of Life
(East Carolina University, 2018-07-20)Fatigue is a problematic symptom that has only recently gained attention in the literature for pediatric sickle cell disease (SCD). Research has established that fatigue is prevalent, persistent, and impairing, though much ... -
Multifunctional experimental assessment in a newly established Mediterranean restored marsh : marsh elevation, carbon accumulation and pollutant concentration reduction
(East Carolina University, 2014)The Delta of the Ebro River (Catalonia, Spain) is among the most important marsh areas in the Western Mediterranean Sea, highly valuable both economically and ecologically. Fluvial sediment reduction by dams in a relative ... -
Multilevel Discourse Processing Analyses in Adults with a Cognitive Impairment
(East Carolina University, 2016-12-13)Participants with a cognitive impairment associated with Alzheimer's disease (AD) present with discourse impairments early within the disorder. These discourse impairment are associated with declines in episodic, semantic, ... -
Multiple Factors Influence the Strength of Intraguild Interactions
(East Carolina University, 2011)Species engaged in intraguild predation (IGP) not only compete for the same food resources but can also eat each other. In some cases, a predator species in a higher trophic position (i.e., a top predator) can eat a ... -
Multiple Translation Factor eIF4G (IFG-1) Isoforms are Required for the Apoptosome-Dependent Activation of Germ Cell Apoptosis
(East Carolina University, 2010)Apoptosis is a naturally occurring process during animal development required for the programmed killing and removal of injured cells. Cellular insult induces a switch in translation that allows for the rapid synthesis ... -
Muscle Mitochondria in Vascular Disease: A Novel Genetic Target for Limb Salvage
(East Carolina University, 2022-04-19)Peripheral arterial occlusive disease (PAD) is a manifestation of systemic atherosclerosis defined by an occlusion in the peripheral arteries, most commonly those supplying blood to the lower extremities. Chronic limb ... -
Musculoskeletal Disorders in Perioperative Personnel and Related Factors
(East Carolina University, 2021-11-29)Background: The nursing profession is physically demanding with increased rates of occupational injuries. Operating room nurses (ORNs) experience rates of musculoskeletal disorders (MSDs) between 66.1% to 92.5%. Surgical ... -
N-3 polyunsaturated fatty acids differentially enhance B-cell mediated immunity in lean and obese mice
(East Carolina University, 2014)Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are bioactive n-3 polyunsaturated fatty acids (PUFAs) in fish oil that exert immunomodulatory effects. The general paradigm suggests n-3 PUFAs exert immunosuppressive ...