Browsing Dissertations by Author "Knudson, Warren"
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CRISPR/Cas9 knockout of HAS2 in rat chondrosarcoma chondrocytes demonstrates the requirement of hyaluronan for aggrecan retention
Huang, Yi (East Carolina University, 2016-12-15)Hyaluronan (HA) plays an essential role in cartilage where it functions to retain aggrecan. Previous studies suggested that aggrecan is anchored indirectly to the plasma membrane of chondrocytes via its binding to ... -
The extracellular processing of aggrecan aggregate and its effect on CD44 mediated internalization of hyaluronan.
Danielson, Ben (East Carolina University, 2015)In many cells the hyaluronan receptor CD44 mediates the endocytosis of hyaluronan and its delivery to endosomes / lysosomes. The regulation of this process remains largely unknown. In most extracellular matrices hyaluronan ... -
The intracellular proteolytic fragment of CD44 alters CD44 function in chondrocytes
Mellor, Liliana (East Carolina University, 2010)CD44 is an adhesion molecule involved in several biological functions and the primary receptor for hyaluronan (HA). In cartilage, CD44 participates in the interplay between cells and the extracellular matrix to fine tune ...