Browsing Dissertations by Author "Mannie, Mark D."
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Antigen-specific tolerogenic vaccines inhibit autoimmune disease in a rodent model of multiple sclerosis
Blanchfield, Jennifer (East Carolina University, 2010)Multiple sclerosis (MS) is considered to be a T cell-mediated autoimmune disease directed against myelinated nerves within the central nervous system. Current therapies available to MS patients have low efficacy and are ... -
Experimental autoimmune encephalomyelitis as a model of Multiple Sclerosis : pathogenesis of atypical disease and tolerance induction in chronic progressive disease
Curtis II, Alan Dale (East Carolina University, 2015)Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) of putative autoimmune origin characterized by focal inflammatory lesions together with demyelinating plaques in the ... -
Selection and stabilization of CD25high FOXP3+ regulatory T cells in vitro as a basis for adoptive antigen-specific immunotherapy
Wilkinson, Daniel Stephen (East Carolina University, 2017-08-16)Autoimmune disease affects an estimated 50 million people in the United States. Autoimmune disease arises when immune tolerance is abrogated and host immune cells mount an attack against self-tissues. For example, in ... -
A SINGLE-CHAIN GMCSF-MOG TOLEROGENIC VACCINE EXPANDS MOG-SPECIFIC CD25+ FOXP3+ REGULATORY T CELLS THROUGH LOW-EFFICIENCY ANTIGEN RECOGNITION EVENTS TO INHIBIT EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
Moorman, Cody Deumont (2019-12)Previous studies showed that tolerogenic vaccines comprised of single-chain GMCSF-neuroantigen (NAg) fusion proteins inhibited experimental autoimmune encephalomyelitis (EAE) in rodents. The studies detailed here provide ...