Understanding the regulation of cellular metabolism is paramount to treating the growing prevalence of metabolic disease worldwide. In cellular metabolism, mitochondrial oxidative phosphorylation (OXPHOS) plays a key role ...

Obese individuals exhibit skeletal muscle metabolic inflexibility by failing to increase fat oxidation and genes linked with mitochondrial biogenesis in response to a high-fat diet (HFD) and lipid incubation in cell culture. ...