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Measured Resting Energy Expenditure Using a Fixed Function Indirect Calorimeter in the Clinical Setting as a Predictor of Success with Weight Change in an Obese Pediatric Population
(East Carolina University, 2010)
The American Dietetic Association (ADA) standard of care for obese adults utilizes indirect calorimetry for calculating caloric targets for weight loss (1). Even though rates appear to be leveling off (2), childhood obesity ...
The Influence of Energy Expenditure on Mitochondrial Functions, Oxidative Stress and Insulin Resistance under Metabolic Oversupply Conditions
(East Carolina University, 2011)
Mitochondrial respiratory capacity and oxidative stress have been implicated in the development of insulin resistance (IR) and type II diabetes. A causative role of mitochondrial oxidative stress in the etiology of ...
NOVEL MECHANISMS GOVERNING SKELETAL MUSCLE MITOCHONDRIAL BIOENERGETICS : OXPHOS EFFICIENCY AND cAMP/PKA SIGNALING
(East Carolina University, 2014)
Understanding the regulation of cellular metabolism is paramount to treating the growing prevalence of metabolic disease worldwide. In cellular metabolism, mitochondrial oxidative phosphorylation (OXPHOS) plays a key role ...
Targeting the mitochondrial inner membrane to improve bioenergetics in the diseased heart
(East Carolina University, 2014)
Cardiovascular diseases continue to exact unparalleled economic and humanitarian costs across the globe. Manifestations of cardiovascular diseases include acute coronary syndromes and heart failure, both of which are ...