Browsing Master's Theses by Author "Georgakilas, Alexandros G."
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Analysis of Complex DNA Damage Associated with Tumor Growth
Ferguson, Nicholas Foster (East Carolina University, 2012)The innate response of a fully functioning immune system's ability to recognize and react to the growth of a tumor by releasing reactive oxygen species (ROS) may lead to chronic inflammation in many cases. This chronic ... -
Repair of Clustered DNA Lesions in Double Strand Break Repair Deficient Human Tumor Cells
Loftin, Charles William (East Carolina University, 2010)DNA-dependent protein kinase (DNA-PK) is a holoenzyme of three subunits, Ku70, Ku80, and the DNA-Pk catalytic subunit (DNA-PKcs). DNA-PK serves a role in non-homologous end joining to repair double stranded breaks, and ... -
Tumor Growth Induces Oxidative Clustered DNA Lesions Damage in Distant Mouse Tissue in vivo
Kryston, Thomas (East Carolina University, 2010)Our goal was to ascertain if DNA damage induced by oxidative stress is capable of being exploited as a precancerous or cancer biomarker. The specific DNA damage that we assessed was oxidatively induced non-DSB clustered ...