Browsing College of Health and Human Performance by Issue Date
Now showing items 41-60 of 808
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Deletion of the Protein Kinase A/Protein Kinase G Target SMTNL1 Promotes an Exercise-adapted Phenotype in Vascular Smooth Muscle
(East Carolina University, 2008-04-25)In vivo protein kinases A and G (PKA and PKG) coordinately phosphorylate a broad range of substrates to mediate their various physiological effects. The functions of many of these substrates have yet to be defined genetically. ... -
Impact of Hormone Replacement Therapy on Exercise Training-Induced Improvements in Insulin Action in Sedentary Overweight Adults
(East Carolina University, 2008-07)Exercise training (ET) and hormone replacement therapy (HRT) are both recognized influences on insulin action, but the influence of HRT on responses to ET has not been examined. In order to determine if HRT use provided ... -
Exercise Fails to Improve Neurocognition in Depressed Middle-Aged and Older Adults
(East Carolina University, 2008-07)Purpose: Although cross-sectional studies have demonstrated an association between higher levels of aerobic fitness and improved neurocognitive function, there have been relatively few interventional studies investigating ... -
Physical activity across the curriculum: year one process evaluation results
(East Carolina University, 2008-07-07)Background: Physical Activity Across the Curriculum (PAAC) is a 3-year elementary school-based intervention to determine if increased amounts of moderate intensity physical activity performed in the classroom will diminish ... -
Does AMP-Activated Protein Kinase Negatively Mediate Aged Fast-Twitch Skeletal Muscle Mass?
(East Carolina University, 2008-10)The activity of 5'-adenosine monophosphate–activated protein kinase, a negative regulator of cell size, is up-regulated with age in resting and overloaded fast-twitch skeletal muscle but not slowtwitch muscle. Here, we ... -
Modulation of IKKβ with AMPK Improves Insulin Sensitivity in Skeletal Muscle
(East Carolina University, 2008-11)Activation of the insulin receptor substrate (IRS)-1 is necessary for proper transduction of the insulin signal. IRS-1 serine312(human)/307(rodent) phosphorylation, however, results in disruption of this signal and subsequent ... -
Muscle work is biased toward energy generation over dissipation in non-level running
(East Carolina University, 2008-12-05)This study tested the hypothesis that skeletal muscles generate more mechanical energy in gait tasks that raise the center of mass compared to the mechanical energy they dissipate in gait tasks that lower the center of ... -
AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exercise
(East Carolina UniversityEast Carolina University, 2008-12-15)5 -AMP-activated protein kinase(AMPK)is a metabolic fuel sensor that monitors cellular energy charge, while the vasculature is important for maintaining cellular energy homeostasis. Mice with muscle-specific inactive AMPK ... -
Recreational Therapy Services and the Functional Independence of Inpatient Pediatric Population
(East Carolina University, 2009)Recreational Therapy (RT) is a relatively new and growing profession with an expanding body of literature. The benefits of RT services have been demonstrated through research studies for several decades. However; there is ... -
Does Minimally Invasive Robotic Surgical Treatment Alter Exercise Tolerance in Patients with Atrial Fibrillation and Mitral Regurgitation at Seven to Eleven Weeks Post-Operative?
(East Carolina University, 2009)In the current study, we examined if exercise tolerance was going to be reduced in atrial fibrillation and mitral valve regurgitation patients post a minimally invasive surgery seven to eleven weeks when compared to ... -
Physical Activity, Academic Performance, and Physical Self-Description in Adolescent Females
(East Carolina University, 2009)Despite the many health benefits of being physically active, nearly a quarter of U.S. adults and adolescents report no participation in leisure-time physical activity. It is recommended that children and adolescents ... -
Chronic low-frequency rTMS of primary motor cortex diminishes exercise training-induced gains in maximal voluntary force in humans
(East Carolina University, 2009)Although there is consensus that the central nervous system mediates the increases in maximal voluntary force (maximal voluntary contraction, MVC) produced by resistance exercise, the involvement of the primary motor cortex ... -
Metabolic Inflexibility in Skeletal Muscle With Obesity
(East Carolina University, 2009)The skeletal muscle of obese individuals has a reduced capacity to oxidize lipids. The hypothesis to be tested in this dissertation is that the ability to regulate lipid oxidation in response to lipid exposure is impaired ... -
Muscle Work Discrepancy during Incline and Decline Running at Three Speeds
(East Carolina University, 2009)Introduction: Previous research has explored muscle function during gait and this work has shown that more positive mechanical muscle work is produced in gait tasks that primarily raise the center of mass (incline gait ... -
Gender Differences in Aerobic and Work Capacity During Plantar Flexion Exercise
(East Carolina University, 2009)Maximal oxygen consumption (VO2max) is lower in females compared to males during traditional whole body, systemic exercise. These differences in VO2max between men and women are still present even after correcting for ... -
Effect of Acute Exercise or Fasting on Mitochondrial Function and High Fat Diet-Induced Insulin Resistance
(East Carolina University, 2009)A high-fat diet leads to an accumulation of lipid in skeletal muscle, and the development of both mitochondrial dysfunction and insulin resistance. Recently, our lab reported that lipid overload leads to elevated ... -
Effect of Duodenal-Jejunal Bypass on Skeletal Muscle Insulin Signaling in Goto-Kakizaki Rats
(East Carolina University, 2009)Gastric bypass surgery (RYGBP) for the treatment of obesity has proven to clinically reverse type 2 diabetes mellitus. RYGBP involves both gastric reduction and bypass of the proximal small intestine. Duodenal-Jejunal ... -
5'-AMP-Activated Protein Kinase and Eukaryotic Elongation Factor 2 Response to Resistance Exercise in Young Versus Old Men and Women
(East Carolina University, 2009)It has been shown that skeletal muscle 5'-AMP-activated protein kinase (AMPK) phosphorylation and/or activity is more greatly elevated in response to resistance exercise or loading in aged rats, and that eukaryotic elongation ... -
Effects of Parental Obesity on Fat Metabolism During Submaximal Exercise in Children
(East Carolina University, 2009)The aim of the present study was to compare fat metabolism during submaximal exercise in children with a morbidly obese parent - (COP) (BMI [greater than or equal to] 40 kg/m²) to children with relatively lean parents - ... -
Exploring the Lived Experiences of Individuals with Tattoos
(East Carolina University, 2009)The purpose of this qualitative phenomenological study was to explore and understand the perceived meaning of tattoo(s) for individuals with tattoos and the decisions, dimensions, and intentions related to the tattooing ...