Type 2 Diabetes Mellitus (T2DM) resolution following Roux-en Y gastric bypass (RYGB) surgery is reduced in patients with longer duration of T2DM and preliminary data suggest this may be mechanistically linked to lower ...

Cardiovascular complications involving both microvascular and macrovascular tissues are the major cause of morbidity and mortality in obese patients. Clinical and epidemiological studies suggest that erectile dysfunction ...

Obese individuals exhibit skeletal muscle metabolic inflexibility by failing to increase fat oxidation and genes linked with mitochondrial biogenesis in response to a high-fat diet (HFD) and lipid incubation in cell culture. ...

Premenopausal women demonstrate preferential accumulation of adiposity in the gynoid region, a distribution which shifts towards the abdominal region after the menopausal transition. Although estrogen is implicated as a ...