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Metabolic Inflexibility in Response to Lipid Oversupply with Obesity: Epigenetic Modifications Play a Role
(East Carolina University, 2013)
The ability to adjust substrate oxidation according to nutrient availability has been termed `metabolic flexibility' and is a critical factor in overall metabolic health. In respect to fatty acid oxidation (FAO) metabolic ...
High-Fat Diet Induced Obesity Increases Serum Myostatin, but Does Not Accelerate Skeletal Muscle Atrophy
(East Carolina University, 2013)
Myostatin is a potent negative regulator of muscle mass, i.e. high levels of myostatin induce loss of muscle. Surprisingly, severely obese humans and obese mice have elevated levels of serum myostatin, but the role of ...
EFFECTS OF MODERATE AEROBIC EXERCISE ON THE ATTENUATION OF LEAN MASS LOSS DURING RAPID WEIGHT LOSS
(East Carolina University, 2013)
Background: Obesity has become a severe issue in the United States, and gastric bypass surgery has been one of the most successful tools to combat the adverse consequences of this disease. The rapid weight loss associated ...
ASSESSMENT OF HOW INTERNALIZED FORMS OF MOTIVATION MEDIATE THE RELATIONSHIP BETWEEN SUPPORTS FOR BASIC PSYCHOLOGICAL NEEDS AND PHYSICAL ACTIVITY BEHAVIORS
(East Carolina University, 2013)
The prevalence of obesity has increased steadily over the last 30 years and it is a growing concern for school, health and recreation providers. Decreases in time spent in physical activity and increased participation in ...
EFFECT OF A TELEPHONE-BASED INTERVENTION ON PHYSICAL ACTIVITY AND COMPONENTS OF THE METABOLIC SYNDROME IN ADOLESCENTS
(East Carolina University, 2013)
The purpose of this study was to determine the effects of a two month telephone-based intervention in obese adolescents (BMI percentile [greater than or equal to] 95th percentile) on physical activity habits and motivation ...
THE EFFECT OF CONTRACTILE ACTIVITY AND SUBSTRATE CHALLENGES ON METABOLIC FLEXIBILITY IN HUMAN PRIMARY MYOTUBES
(East Carolina University, 2013)
The skeletal muscle of severely obese individuals (BMI > 40 kg/m²) is characterized by a depressed ability to oxidize fatty acids and a failure to upregulate fatty acid oxidation (FAO) in response to increased lipid ...
Effects of obesity on the transcriptional regulation of protein degradation in skeletal muscle
(East Carolina University, 2013)
Effects of obesity on the transcriptional regulation of protein degradation in skeletal muscle by Lance M. Bollinger November, 2013 Director of Thesis/Dissertation: Jeffrey J. Brault Major Department: Kinesiology ...