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AMP-activated protein kinase response to contractions and treatment with the AMPK activator AICAR in young adult and old skeletal muscle
(East Carolina University, 2009-05-01)
One characteristic of aging skeletal muscle is a decline in mitochondrial function. Activation of AMP-activated protein kinase (AMPK)occurs in response to an increased AMP/ATP ratio,which is one potential result of ...
Metabolic Inflexibility in Response to Lipid Oversupply with Obesity: Epigenetic Modifications Play a Role
(East Carolina University, 2013)
The ability to adjust substrate oxidation according to nutrient availability has been termed `metabolic flexibility' and is a critical factor in overall metabolic health. In respect to fatty acid oxidation (FAO) metabolic ...
High-Fat Diet Induced Obesity Increases Serum Myostatin, but Does Not Accelerate Skeletal Muscle Atrophy
(East Carolina University, 2013)
Myostatin is a potent negative regulator of muscle mass, i.e. high levels of myostatin induce loss of muscle. Surprisingly, severely obese humans and obese mice have elevated levels of serum myostatin, but the role of ...
Impaired overload-induced muscle growth is associated with diminished translational signalling in aged rat fast-twitch skeletal muscle
(East Carolina University, 2006-07-01)
Impaired overload-induced protein synthesis and growth in aged fast-twitch skeletal muscle may result from diminished responsiveness of signalling intermediates controlling protein translation. Yet, potential age-related ...
Cleaved Caspase-3 Response to Acute Resistance Exercise in Young and Old Men and Women : Relationship to Muscle Glycogen Content and 5'-AMP-Activated Protein Kinase (AMPK) Activity
(East Carolina University, 2011)
In addition to suppressing protein synthesis and activating protein degradation in skeletal muscle and other cell types, 5'-AMP-activated protein kinase (AMPK) is known to stimulate nuclear apoptosis in non-muscle cells ...
Metabolic Inflexibility in Skeletal Muscle With Obesity
(East Carolina University, 2009)
The skeletal muscle of obese individuals has a reduced capacity to oxidize lipids. The hypothesis to be tested in this dissertation is that the ability to regulate lipid oxidation in response to lipid exposure is impaired ...
Transcriptional regulation of muscle fatty acid-binding protein.
(East Carolina University, 1994-03-15)
Heart fatty acid-binding protein (H-FABP) is present in a wide variety of tissues but is found in the highest concentration in cardiac and red skeletal muscle. It has been proposed that the expression of H-FABP correlates ...
No difference in the skeletal muscle angiogenic response
(East Carolina University, 2007-11)
Ischaemia-induced skeletalmuscle angiogenesis is impaired in aged compared with young mice. In humans, vascular endothelial growth factor (VEGF) mRNA and protein following an acute exercise bout are lower in aged compared ...
Intramuscular lipid oxidation and obesity
(East Carolina University, 2008-04)
There is an accumulating amount of evidence indicating that lipid oxidation is depressed in the skeletal muscle of obese individuals. Decrements in fatty acid oxidation (FAO) have been reported with obesity in models ranging ...
A sex-specific relationship between capillary density and anaerobic threshold
(East Carolina University, 2009-04)
Although both capillary density and peak oxygen consumption (VO2) improve with exercise training, it is difficult to find a relationship between these two measures. It has been suggested that peak VO2 may be more related ...