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5'-AMP-Activated Protein Kinase and Eukaryotic Elongation Factor 2 Response to Resistance Exercise in Young Versus Old Men and Women
(East Carolina University, 2009)
It has been shown that skeletal muscle 5'-AMP-activated protein kinase (AMPK) phosphorylation and/or activity is more greatly elevated in response to resistance exercise or loading in aged rats, and that eukaryotic elongation ...
A single dose of metformin improves whole body insulin sensitivity and alters cellular redox state in skeletal muscle of Zucker fa/fa rats
(East Carolina University, 2010)
Energy balance is considered a fundamental requirement of life forms from single cell organisms to higher mammals such as humans. Unfortunately, our species has also discovered the detrimental metabolic responses to excess ...
Modulation of IKKβ with AMPK Improves Insulin Sensitivity in Skeletal Muscle
(East Carolina University, 2008-11)
Activation of the insulin receptor substrate (IRS)-1 is necessary for proper transduction of the insulin signal. IRS-1 serine312(human)/307(rodent) phosphorylation, however, results in disruption of this signal and subsequent ...
Regulation of Lipolysis By Perilipin : influence of Obesity and Exercise Training
(East Carolina University, 2010)
Obesity is the result of excess energy storage due to an imbalance between energy storage and energy utilization. Excess energy is stored as triacylglycerol (TAG) in adipose tissue in various regions throughout the body. ...
Effects of Parental Obesity on Fat Metabolism During Submaximal Exercise in Children
(East Carolina University, 2009)
The aim of the present study was to compare fat metabolism during submaximal exercise in children with a morbidly obese parent - (COP) (BMI [greater than or equal to] 40 kg/m²) to children with relatively lean parents - ...
Cleaved Caspase-3 Response to Acute Resistance Exercise in Young and Old Men and Women : Relationship to Muscle Glycogen Content and 5'-AMP-Activated Protein Kinase (AMPK) Activity
(East Carolina University, 2011)
In addition to suppressing protein synthesis and activating protein degradation in skeletal muscle and other cell types, 5'-AMP-activated protein kinase (AMPK) is known to stimulate nuclear apoptosis in non-muscle cells ...
EFFECTS OF A 16 WEEK PHYSICAL ACTIVITY INTERVENTION ON SERUM C-REACTIVE PROTEIN CONCENTRATIONS IN 8-11 YEAR OLD AFRICAN AMERICAN AND CAUCASIAN CHILDREN.
(East Carolina University, 2013)
C-reactive protein (CRP) is a non-specific marker of systemic inflammation that has been associated with heart disease, obesity, and metabolic disorders in adults and children. Previous physical activity interventions have ...
THE ROLE OF LONG-CHAIN ACYL-COENZYME A SYNTHETASE 1 (ACSL-1) IN LIPID METABOLISM IN HUMAN SKELETAL MUSCLE PRIMARY MYOTUBES.
(East Carolina University, 2011)
Obesity is considered a major health threat to the U.S. due to being a strong risk factor for developing type 2 diabetes and other metabolic diseases. The prevalence and severity of obesity is even greater among some ...
The Physiological and Pathological Role of Mitochondrial Calcium in the Diabetic Heart
(East Carolina University, 2011)
Diabetic patients are more susceptible to ischemia/reperfusion injury and cardiac dysfunction likely due alterations in mitochondrial calcium handling. The purpose of this work was to determine if redox-dependent changes ...
Does Minimally Invasive Robotic Surgical Treatment Alter Exercise Tolerance in Patients with Atrial Fibrillation and Mitral Regurgitation at Seven to Eleven Weeks Post-Operative?
(East Carolina University, 2009)
In the current study, we examined if exercise tolerance was going to be reduced in atrial fibrillation and mitral valve regurgitation patients post a minimally invasive surgery seven to eleven weeks when compared to ...