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Now showing items 11-20 of 27
Effect of Acute Exercise or Fasting on Mitochondrial Function and High Fat Diet-Induced Insulin Resistance
(East Carolina University, 2009)
A high-fat diet leads to an accumulation of lipid in skeletal muscle, and the development of both mitochondrial dysfunction and insulin resistance. Recently, our lab reported that lipid overload leads to elevated ...
Intramuscular Lipid Metabolism, Insulin Action and Obesity
(East Carolina University, 2009-01)
With the increasing prevalence of obesity, research has focused on the molecular mechanism(s) linking obesity and skeletal muscle insulin resistance. Metabolic alterations within muscle, such as changes in the cellular ...
Effects of Parental Obesity on Fat Metabolism During Submaximal Exercise in Children
(East Carolina University, 2009)
The aim of the present study was to compare fat metabolism during submaximal exercise in children with a morbidly obese parent - (COP) (BMI [greater than or equal to] 40 kg/m²) to children with relatively lean parents - ...
Relationships between Adipose Tissue and Cytokine Responses to a Randomized Controlled Exercise Training Intervention
(East Carolina University, 2008-04)
Adipose-derived cytokines play a prominent role in mediating the metabolic consequences of obesity and excess body fat. Given this, we hypothesized that alterations in adipose tissue stores incurred with exercise training ...
IL-15 : A NOVEL REGULATOR OF LIPOLYSIS IN HUMANS?
(East Carolina University, 2014)
Interactions between and within organ systems such as skeletal muscle (SkM) and adipose tissue (AT), via immune cell signaling factors (cytokines), may regulate the development of obesity. The increased expression and ...
Effects of High-Insulin Exposure on Mitochondrial Content in Skeletal Muscle Myotubes from Lean & Severely Obese Individuals: A Time Course Analysis
(East Carolina University, 2016-08-01)
Skeletal muscle is the site at which highly regulated energetic processes take place as a means of maintaining both tissue-specific and whole-body metabolism. With the development of severe obesity (BMI [greater-than] or ...
The Relationship between Gait Biomechanics and Body Mass Index
(East Carolina University, 2014)
Walking gait is one of the basic components of human movements. With the rising obesity epidemic and implied health complications, it is pertinent to examine the relationship between body mass index and the joint torques ...
Effects of obesity on the transcriptional regulation of protein degradation in skeletal muscle
(East Carolina University, 2013)
Effects of obesity on the transcriptional regulation of protein degradation in skeletal muscle by Lance M. Bollinger November, 2013 Director of Thesis/Dissertation: Jeffrey J. Brault Major Department: Kinesiology ...
Short-term, high-fat diet accelerates disuse atrophy and protein degradation in a muscle-specific manner in mice
(2015-11-04)
Background:
A short-term high-fat diet impairs mitochondrial function and the ability of skeletal muscle to respond to growth stimuli, but it is unknown whether such a diet alters the ability to respond to atrophy signals. ...
Mitochondrial Oxidative Capacity In Human Skeletal Muscle: Association with Plasma Lactate Concentration
(East Carolina University, 2018-07-11)
ABSTRACT Background: Metabolic disease is a growing concern for public health. Obesity and Type II Diabetes are an epidemic and a phenotype for insulin resistance in human skeletal muscle. A reduced mitochondrial function ...