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AMP Deaminase 3 overexpression regulates cellular energetics and signaling for PGC-1α activation.
(East Carolina University, 2017-06-02)
Skeletal muscles undergoing atrophy have decreased [ATP], PGC-1[alpha] expression, and mitochondrial content. This combination of findings is unexpected because decreased [ATP] is often associated with greater [AMP] and ...
Influence of Pre-pregnancy and During Pregnancy Exercise On Infant Heart Outcomes
(East Carolina University, 2017-06-27)
Maternal exercise during pregnancy is quickly becoming a new norm that has been shown to have benefits for fetal and infant development. Most studies examining the influence of exercise during pregnancy on infant outcomes ...
Early Metabolic Differences in Alzheimer’s Disease Mouse Model and Exercise Intervention Treatment
(East Carolina University, 2017-06-22)
Alzheimer's disease (AD) is a neurodegenerative disorder that affects the central nervous system (CNS). In this study, we characterized and examined the early metabolic changes of the triple transgenic Alzheimer's disease ...
THE IMPACT OF THREE DIFFERENT PHYSICAL ACTIVITY RECOMMENDATIONS ON PHYSICAL ACTIVITY
(East Carolina University, 2017-07-25)
Current physical activity guidelines encourage adults to accumulate 150 minutes of moderate intensity aerobic physical activity each week to improve health. Recommendations based on these guidelines typically focus on ...
Adaptations of the Hypothalamic Arcuate Nucleus in Response to Exercise and Hunger
(East Carolina University, 2018-05-02)
The arcuate nucleus of the hypothalamus serves as a critical node for regulation of mammalian energy balance with the ability to sense the status of many organ systems and exert control over effector arms that potently ...
Mitochondrial Oxidative Capacity In Human Skeletal Muscle: Association with Plasma Lactate Concentration
(East Carolina University, 2018-07-11)
ABSTRACT Background: Metabolic disease is a growing concern for public health. Obesity and Type II Diabetes are an epidemic and a phenotype for insulin resistance in human skeletal muscle. A reduced mitochondrial function ...
Shearwave elastography : a prospective study on short term changes in UCL health of college baseball pitchers
(East Carolina University, 2018-07-31)
The rate of ulnar collateral ligament (UCL) reconstruction surgery, or "Tommy John" surgery, has risen dramatically in baseball pitchers over the last decade. Throughout the baseball pitching motion, the UCL undergoes ...
AMP Deaminase 3 knockout mice and loss of mitochondrial proteins and enzyme activity during denervation atrophy
(East Carolina University, 2018-07-17)
Muscle atrophy leads to decrements in muscle function, partly attributable to decreased mitochondrial content. One controller of mitochondrial content is AMP-activated protein kinase (AMPK), which when bound by AMP activates ...
Regulation of Skeletal Muscle Glucose Transport and Glucose Metabolism by Exercise Training
(2019-10-12)
Aerobic exercise training and resistance exercise training are both well-known for their ability to improve human health; especially in individuals with type 2 diabetes. However, there are critical differences between these ...
Effects of aerobic training with and without weight loss on insulin sensitivity and lipids
(2018-05-18)
Purpose:
The purpose of this study is to evaluate the effect of exercise training with modest or greater weight loss (≥3%) or not (<3%) on insulin sensitivity, lipoprotein concentrations, and lipoprotein particle size ...