Now showing items 1-3 of 3
Notch 3 Affects Chemoresistance in Colorectal Cancer via DNA Base Excision Repair Enzymes
(East Carolina University, 2017-07-28)
Approximately 1.2 million cases of colorectal cancer (CRC) arise each year, and 40-50% of CRC patients will reach metastasis. The Notch pathway is known to be dysregulated in CRC, and its relationship with DNA repair ...
The Role of the Notch-3 Receptor in Stemness, EMT, and Tumorigenesis in Colorectal Cancer
(East Carolina University, 2016-05-05)
As the second leading cause of cancer death worldwide, colorectal cancer (CRC) poses a significant threat to both men and women alike. Although a small percentage of CRC cases are inherited, the majority of cases arise ...
Notch Signaling Mediates Drug Resistance in Colorectal Cancer Cells via Effects on DNA Repair Proteins
(East Carolina University, 2016-07-25)
Colorectal cancer (CRC) is the second leading cause of cancer deaths in the United States and the third most commonly diagnosed cancer in men and women. Despite tremendous progress in diagnosis, prevention, and treatment ...