Browsing Microbiology and Immunology by Submit Date
Now showing items 41-60 of 239
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DELINEATING THE MECHANISM OF AGGREGATE OR BIOFILM FORMATION IN THE LYME DISEASE SPIROCHETE BORRELIA BURGDORFERI
(East Carolina University, 2021-07-14)Borrelia burgdorferi, the spirochete causing Lyme disease, is transmitted to a vertebrate host by the bite of an infected Ixodes scapularis tick. The spirochete develops antibiotic resistance in humans likely due to the ... -
DELINEATING THE ROLE OF SOLUBLE CD25 AS AN IMMUNOREGULATORY MOLECULE THAT PROMOTES A LOW-ZONE IL-2 SIGNALING ENVIRONMENT FAVORABLE FOR THE SELECTION OF CD25HIGH FOXP3HIGH T CELLS
(East Carolina University, 2021-07-22)Autoimmune diseases develop due to the breakdown of tolerogenic mechanisms that normally maintain immune homeostasis. CD4+ CD25+ FOXP3+ regulatory T cells (Tregs) are critical in the maintenance of tolerance and the ... -
NOVEL BIOLOGICS PROMOTE STABLE EXPANSION OF REGULATORY CD25HIGH FOXP3+ T LYMPHOCYTES AS A MEANS FOR AN ADOPTIVE CELL-BASED IMMUNOTHERAPY
(East Carolina University, 2021-06-18)Autoimmune disease arises when a breakdown in immunological self-tolerance causes self-reactive tissue destruction. In Multiple Sclerosis (MS), myelin reactive CD4+ T cells initiate an immune attack on the myelin sheath ... -
Development of small-molecule inhibitors of the initiating proteases, C1r and C1s, of the classical complement pathway
(East Carolina University, 2019-12-12)Complement is a proteolytic cascade that upon activation plays a key effector role in the innate immune system and acts to prime the adaptive immune response. During normal homeostatic events, complement is tightly regulated ... -
A SINGLE-CHAIN GMCSF-MOG TOLEROGENIC VACCINE EXPANDS MOG-SPECIFIC CD25+ FOXP3+ REGULATORY T CELLS THROUGH LOW-EFFICIENCY ANTIGEN RECOGNITION EVENTS TO INHIBIT EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
(2019-12)Previous studies showed that tolerogenic vaccines comprised of single-chain GMCSF-neuroantigen (NAg) fusion proteins inhibited experimental autoimmune encephalomyelitis (EAE) in rodents. The studies detailed here provide ... -
Attenuated viruses and method of making the same
(1996-04-18)Disclosed are attenuated viruses, not naturally occurring, that contain one or more additional methylation sites in the genome of the virus compared to the corresponding wild-type virus. Preferably, the methylation sites ... -
Hox-gene expression as a biomarker for igf-1r therapeutics
(2008-09-25)This invention provides methods for treating or preventing the onset of a tumor in a subject, wherein the tumor is determined to overexpress a Hox gene, including administering to the subject a therapeutically or ... -
Cytokines and neuroantigens for treatment of immune disorders
(2017-05-10)The present invention provides methods of regulating an immunological disorder comprising administering to a subject an effective amount of (i) an autoimmune antigen in conjunction with (ii) an anti-inflammatory cytokine. ... -
Human T-Cell Leukemia Virus Type I Basic Leucine Zipper Factor (HBZ) Modulates Cellular DNA Damage Repair and Antioxidant Responses to Promote Host Cell Survival and Leukemogenesis
(East Carolina University, 2018-04-19)Approximately twenty million people worldwide are infected with Human T-cell Leukemia Virus type 1 (HTLV-1). HTLV-1 establishes a life-long, chronic infection which can result in the development of severe HTLV-1 associated ... -
MICRONOME AND KSHV INFECTION: IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF CELLULAR MICRORNAS DURING VIRUS ENTRY
(East Carolina University, 2018-04-17)Kaposi's sarcoma-associated herpesvirus (KSHV), is the most recently identified human herpesvirus and causes a variety of human malignancies. KSHV is etiologically associated with Kaposi's sarcoma (KS), primary effusion ... -
Selection and stabilization of CD25high FOXP3+ regulatory T cells in vitro as a basis for adoptive antigen-specific immunotherapy
(East Carolina University, 2017-08-16)Autoimmune disease affects an estimated 50 million people in the United States. Autoimmune disease arises when immune tolerance is abrogated and host immune cells mount an attack against self-tissues. For example, in ... -
NOVEL ROLE OF HUMAN T-CELL LEUKEMIA VIRUS TYPE-1 ENCODED PROTEIN HBZ IN VIRAL TRANSMISSION THROUGH CELL-TO-CELL CONTACT
(East Carolina University, 2017-04-28)The complex retrovirus Human T cell leukemia virus type I (HTLV-1) is the etiologic agent of several diseases, including Adult T cell leukemia (ATL), a fatal hematological malignancy that affects mainly CD4+ T-cells. Freshly ... -
Motility and chemotaxis in the Lyme disease spirochete Borrelia burgdorferi : role in pathogenesis
(East Carolina University, 2016-08-18)Lyme disease is the most prevalent vector-borne disease in United States and is caused by the spirochete Borrelia burgdorferi. The disease is transmitted from an infected Ixodes scapularis tick to a mammalian host. B. ... -
Characterization of FtrABCD: a ferrous iron-specific transporter that is required for the virulence of Brucella abortus 2308 in mice
(East Carolina University, 2016-07-21)Brucella strains are Gram-negative bacteria that cause abortion and infertility in their natural animal hosts resulting in extensive economic losses. Humans can acquire a chronic, debilitating febrile illness known as ... -
Targeted therapy for hepatocellular carcinoma: novel agents on the horizon
(2012-03)Hepatocellular carcinoma (HCC) is the most common liver cancer, accounting for 90% of primary liver cancers. In the last decade it has become one of the most frequently occurring tumors worldwide and is also considered to ... -
Involvement of Akt-1 and mTOR in Sensitivity of Breast Cancer to Targeted Therapy
(2011-07)Elucidating the response of breast cancer cells to chemotherapeutic and hormonal based drugs is clearly important as these are frequently used therapeutic approaches. A signaling pathway often involved in chemo- and ...