Browsing Microbiology and Immunology by Author "Coleman, James P."
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Cloning and characterization of a conjugated bile acid hydrolase gene from Clostridium perfringens.
Coleman, James P.; Hudson, L. Lynn (East Carolina University, 1995-07)The gene encoding a conjugated bile acid hydrolase (CBAH) from Clostridium perfringens 13 has been cloned and expressed in Escherichia coli, and its nucleotide sequence has been determined. Nucleotide and predicted amino ... -
Interference with Pseudomonas quinolone signal synthesis inhibits virulence factor expression by Pseudomonas aeruginosa
Calfee, M. Worth; Coleman, James P.; Pesci, Everett C. (East Carolina University, 2001-09-25)Pseudomonas aeruginosa is an opportunistic pathogen that controls numerous virulence factors through intercellular signals. This bacterium has two quorum-sensing systems (las and rhl), which act through the intercellular ... -
Oxidative stress response in an anaerobe, Bacteroides fragilis: a role for catalase in protection against hydrogen peroxide.
Rocha, Edson R.; Selby, Tina; Coleman, James P.; Smith, C. Jeffrey (East Carolina University, 1996-12)Survival of Bacteroides fragilis in the presence of oxygen was dependent on the ability of bacteria to synthesize new proteins, as determined by the inhibition of protein synthesis after oxygen exposure. The B. fragilis ... -
PqsE Functions Independently of PqsR-Pseudomonas Quinolone Signal and Enhances the rhl Quorum-Sensing System
Farrow, John M. III; Sund, Zoe M.; Ellison, Matthew L.; Wade, Dana S.; Coleman, James P.; Pesci, Everett C. (East Carolina University, 2008-11)Pseudomonas aeruginosa is an opportunistic pathogen that causes both acute and chronic infections in immunocompromised individuals. This gram-negative bacterium produces a battery of virulence factors that allow it to ... -
Pseudomonas aeruginosa PqsA Is an Anthranilate-Coenzyme A Ligase
Coleman, James P.; Hudson, L. Lynn; McKnight, Susan L.; Farrow, John M. III; Calfee, M. Worth; Lindsey, Claire A.; Pesci, Everett C. (East Carolina University, 2008-02)Pseudomonas aeruginosa is an opportunistic human pathogen which relies on several intercellular signaling systems for optimum population density-dependent regulation of virulence genes. The Pseudomonas quinolone signal ... -
Regulation of Pseudomonas Quinolone Signal Synthesis in Pseudomonas aeruginosa
Wade, Dana S.; Calfee, M. Worth; Rocha, Edson R.; Ling, Elizabeth A.; Engstrom, Elana; Coleman, James P.; Pesci, Everett C. (East Carolina University, 2005-07)Pseudomonas aeruginosa is an opportunistic pathogen that causes chronic lung infections in cystic fibrosis patients and is a major source of nosocomial infections. This bacterium controls many virulence factors by using ...